Scientific Study

The highly processed; calorie-dense; nutrient-depleted diet favored in the current American culture frequently leads to exaggerated supraphysiological post-prandial spikes in blood glucose and lipids. This state; called postprandial dysmetabolism; induces immediate oxidant stress; which increases in direct proportion to the increases in glucose and triglycerides after a meal. The transient increase in free radicals acutely triggers atherogenic changes including inflammation; endothelial dysfunction; hypercoagulability; and sympathetic hyperactivity. Post-prandial dysmetabolism is an independent predictor of future cardiovascular events even in nondiabetic individuals. Improvements in diet exert profound and immediate favorable changes in the post-prandial dysmetabolism. Specifically; a diet high in minimally processed; high-fiber; plant-based foods such as vegetables and fruits; whole grains; legumes; and nuts will markedly blunt the post-meal increase in glucose; triglycerides; and inflammation. Additionally; lean protein; vinegar; fish oil; tea; cinnamon; calorie restriction; weight loss; exercise; and low-dose to moderate-dose alcohol each positively impact post-prandial dysmetabolism. Experimental and epidemiological studies indicate that eating patterns; such as the traditional Mediterranean or Okinawan diets; that incorporate these types of foods and beverages reduce inflammation and cardiovascular risk. This anti-inflammatory diet should be considered for the primary and secondary prevention of coronary artery disease and diabetes.