Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-allergic Children with Atopic Comorbidities
Background: There is a high prevalence rate of atopic comorbidities, including atopic dermatitis (AD), asthma, and concomitant food allergy (CFA), in children with peanut allergy. Objective: To evaluate whether concomitant atopic comorbidities affect the safety and efficacy of VIASKIN® peanut patch (VP250). Methods: EPITOPE was a phase 3, double-blind, placebo-controlled trial designed to assess treatment […]
Citrin: a novel food allergen in citrus seeds and citrus-derived pectin that shows cross-reactivity with cashew and pistachio
Background: Patients exquisitely sensitive to cashew/pistachio are at risk for allergic reactions to citrus seeds and pectin. Objective: In this study, we sought to examine whether pectin is contaminated with citrus seeds, to identify a culprit antigen in citrus seeds, and to assess for cross-reactivity among allergens in citrus seeds, citrus pectin, and cashew/pistachio. Methods: […]
Interaction of mediators and effector cells in cashew nut-induced anaphylaxis
Background: The underlying mechanisms of an immediate food-induced allergic reaction involve mast-cell degranulation and recruitment of other effector cells, such as lymphocytes, eosinophils, and basophils. How the interaction of various mediators and cells results in anaphylaxis is not fully understood. Objective: To evaluate changes in platelet-activating factor (PAF), platelet-activating factor acetylhydrolase (PAF-AH), tryptase, eosinophils, basophils, […]
Factors associated with home epinephrine-treated reactions during peanut and tree-nut oral immunotherapy.
Background: Home reactions requiring epinephrine administration, a marker of their severity, restrict the widespread use of oral immunotherapy (OIT), but their risk factors are largely not known. Objective: To identify risk factors for such reactions during OIT to most allergenic foods. Methods: All patients who began OIT for peanut, tree nuts, sesame, or egg allergy […]
Tree Nut-Induced Anaphylaxis in Canadian Emergency Departments: Rate, Clinical Characteristics and Management.
Background: Data are sparce regarding tree nut-induced anaphylaxis (TNA). Objective: We aimed to characterize rate, clinical characteristics, and management of TNA in children (0-17 years old) across Canada, and assess factors associated with severe reactions and epinephrine use. Methods: Between April 2011 and May 2020, data were collected on children presenting to five emergency departments (EDs) in Canada. […]
Real-life experience with hazelnut oral immunotherapy.
Background: Hazelnut oral immunotherapy (H-OIT), a promising alternative to hazelnut-free diet for patients with hazelnut allergy, has not been extensively studied. Objective: The primary objective was to investigate the effectiveness of H-OIT for hazelnut allergic children. Methods: Retrospective medical record review of children treated by H-OIT in the University Hospital of Lyon (France) was reported. Clinical and laboratory […]