Daily consumption of unsalted, skin-roasted peanuts beneficially affects regional brain insulin responsiveness in older adults: results of a longer-term randomized controlled trial
Brain insulin responsiveness is implicated in age-related metabolic and cognitive conditions. We previously reported that daily consumption of unsalted, skin-roasted peanuts improved memory in older adults. Here, we investigated whether changes in brain insulin responsiveness may contribute to these effects. In a randomized, single-blind, controlled crossover study, 31 older adults (67 ± 4 years) consumed […]
Turkish Hazelnut Extracts Exert Anti-Proliferative and Anti-Cancer Effects on Colorectal Cancer HCT-116 Cells
Walnuts (Juglans regia L.) are attracting increasing interest from consumers, industries, and the healthcare community due to their high content of bioactive compounds, including (poly)phenols, carotenoids, tocopherols, and omega-3 fatty acids. Despite the continued growth in global walnut production, the effective valorisation of walnut processing by-products remains a challenge. While most research has focused on […]
Daily walnut consumption increases 6-sulfatoxymelatonin urinary levels and can improve sleep quality: a randomized crossover trial
We aimed to study the potential impact of daily consumption of walnuts on urinary 6-sulphatoxymelatonin (6-SMT) levels and sleep quality parameters. We conducted an open-label randomized crossover trial (NCT04799821) in 76 young adults (24.1 ± 3.4 years; 85.5% women) who either ingested 40 g of walnuts daily during dinner (intervention) or refrained from eating walnuts […]
Effects of hazelnut protein isolate-induced food allergy on the gut microenvironment in a BALB/c mouse model
Hazelnuts are reported as among the nuts that cause severe allergic reactions. However, few systematic studies exist on the changes in the gut microenvironment following hazelnut allergy. This study focused on the effects of hazelnut allergy on the duodenum, jejunum, ileum and colon microenvironment in vivo. We established a hazelnut protein isolate (HPI)-allergic mouse model, […]
Non-thermal processing of cashews: irradiation reduces allergenicity by altering the structure of Ana o 3.
Traditional thermal processing of cashews not only results in nutrient loss and harmful by-products, but also does not significantly reduce allergenicity. Irradiation could be an important non-thermal processing method to reduce cashew allergens’ allergenicity and retain their nutritional properties. This study aimed to evaluate the effects of gamma irradiation processing on the structure and potential […]
Daily consumption of cranberry improves endothelial function in healthy adults: a double blind randomized controlled trial
Background: Previous studies indicate cardiovascular health benefits of cranberry juice consumption. However, whether daily consumption of whole cranberries will have sustained vascular benefits in healthy individuals is currently unknown. Objective: To investigate the vascular effects of acute and daily consumption of freeze dried whole cranberry in healthy men and how effects relate to circulating cranberry (poly)phenol […]
Pine nut antioxidant peptides ameliorate the memory impairment in a scopolamine-induced mouse model via SIRT3-induced synaptic plasticity.
This study aimed to investigate the effects of a pine nut albumin hydrolysate (fraction <3 kDa) and of its short peptide derivative, Trp-Tyr-Pro-Gly-Lys (WYPGK), on synaptic plasticity and memory function in scopolamine-induced memory-impaired mice, as well as the potential underlying mechanism in PC12 cells. In the scopolamine-induced mouse model, the results revealed that the fraction […]