Validation of the NUT CRACKER diagnostic algorithm and prediction for cashew and pistachio co-allergy
Background: Due to the high cross sensitization among tree nuts, the NUT CRACKER study proposed a diagnostic algorithm to minimize the number of required oral food challenges (OFC). Objective: The objective of this study was to validate the algorithm for cashew and pistachio allergy and determine markers for allergic severity. Methods: Patients (n=125) aged 7.9 […]
Combining allergen components improves the accuracy of peanut allergy diagnosis.
Background: IgE to peanut often occurs in the absence of peanut allergy. Detection of allergen component sIgE has improved diagnosis and birthed molecular allergen component arrays, in which sensitisation to multiple allergen components can be measured simultaneously. Objective: To improve the diagnostic utility of serology for peanut allergy, by mapping interactions of sIgE to multiple […]
Peanut can be used as a reference allergen for hazard characterization in food allergen risk management: A rapid evidence assessment and meta-analysis.
Regional and national legislation mandates the disclosure of "priority" allergens when present as an ingredient in foods, but this does not extend to the unintended presence of allergens due to shared production facilities. This has resulted in a proliferation of precautionary allergen ("may contain") labels (PAL) which are frequently ignored by food-allergic consumers. Attempts have […]
Clinical predictors and outcomes of oral food challenges illustrate differences among individual tree nuts.
Background. Although allergy to tree nuts is often considered a single entity, there is heterogeneity in patient reactivity and immune response to different tree nuts. Objective. We sought to characterize tree nut oral food challenges (OFC) in a pediatric population performed at a single center over a 12-year period and determine differences in OFC outcome […]
Increased Rates of Peanut and Tree Nut Aspiration as a Possible Consequence of Allergy Prevention by Early Introduction
Background: Pediatric airway foreign bodies (FBs) are a surgical emergency, and peanuts and tree nuts (PN/TNs) can pose a significant aspiration risk in young children. In 2015, the Learning Early About Peanut allergy (LEAP) trial established that early introduction of peanuts in high-risk infants reduced the risk of developing a peanut allergy. Infant feeding guidelines were […]
Predicting the Natural Development of Peanut Tolerance using Longitudinal Trajectories of Peanut-specific Serum Immunoglobulin E
No abstract available
The accuracy of diagnostic testing in determining tree nut allergy: a systematic review.
Background: Food allergy is most accurately diagnosed by a formal oral food challenge however it is time and labor intensive, risks the individual to severe reaction and access is often a limiting step in the diagnostic process. This is compounded for tree nut allergy diagnosis as several oral food challenges may be required to determine allergy […]
Basophil activation test reduces oral food challenges to nuts and sesame.
Background: Nut allergic patients are often IgE sensitized to other nuts/seeds and need multiple oral food challenges (OFCs) before the safe nuts can be introduced in the diet. However, OFCs are time-consuming and risky procedures. Objective: To assess the utility of the basophil activation test (BAT) to predict the allergic status and reduce the need for an […]
Accurate prediction of peanut allergy in one-third of adults using a validated Ara h 2 cutoff.
Background: The diagnostic value of peanut components is extensively studied in children, but to a lesser extent in adults with suspected peanut allergy. The use of peanut components in daily practice may reduce the need for double-blind placebo-controlled food challenges (DBPCFCs), however validation studies are currently lacking. Objective: To 1) evaluate the diagnostic value of (combined) peanut […]
Irradiated Tree Nut Flours for Use in Oral Immunotherapy.
Background: Tree nut allergies affect an estimated 1% of the United States population and is lifelong in 90% of allergic individuals. Oral immunotherapy (OIT) for food allergies is an effective method to induce desensitization in a majority of participants in trials of peanut, egg, and milk OIT. Limited trials using tree nut OIT have been reported, […]