AR101 oral immunotherapy for peanut allergy.
BACKGROUND: Peanut allergy, for which there are no approved treatment options, affects patients who are at risk for unpredictable and occasionally life-threatening allergic reactions. METHODS: In a phase 3 trial, we screened participants 4 to 55 years of age with peanut allergy for allergic dose-limiting symptoms at a challenge dose of 100 mg or less […]
Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy
BACKGROUND. The prevalence of peanut allergy among children in Western countries has doubled in the past 10 years, and peanut allergy is becoming apparent in Africa and Asia. We evaluated strategies of peanut consumption and avoidance to determine which strategy is most effective in preventing the development of peanut allergy in infants at high risk for […]
Effect of Avoidance on Peanut Allergy after Early Peanut Consumption.
Background In a randomized trial, the early introduction of peanuts in infants at high risk for allergy was shown to prevent peanut allergy. In this follow-up study, we investigated whether the rate of peanut allergy remained low after 12 months of peanut avoidance among participants who had consumed peanuts during the primary trial (peanut-consumption group), […]
Randomized trial of peanut consumption in infants at risk for peanut allergy
Association of nut consumption with total and cause-specific mortality
Changes in diet and lifestyle and long-term weight gain in women and men
BACKGROUND: Specific dietary and other lifestyle behaviors may affect the success of the straightforward-sounding strategy "eat less and exercise more" for preventing long-term weight gain. METHODS: We performed prospective investigations involving three separate cohorts that included 120;877 U.S. women and men who were free of chronic diseases and not obese at baseline; with follow-up periods […]
Changes in diet and lifestyle and long-term weight gain in women and men
BACKGROUND: Specific dietary and other lifestyle behaviors may affect the success of the straightforward-sounding strategy "eat less and exercise more" for preventing long-term weight gain. METHODS: We performed prospective investigations involving three separate cohorts that included 120;877 U.S. women and men who were free of chronic diseases and not obese at baseline; with follow-up periods […]