Omalizumab for the Treatment of Multiple Food Allergies
BACKGROUND: Food allergies are common and are associated with substantial morbidity; the only approved treatment is oral immunotherapy for peanut allergy. METHODS: In this trial, we assessed whether omalizumab, a monoclonal anti-IgE antibody, would be effective and safe as monotherapy in patients with multiple food allergies. Persons 1 to 55 years of age who were […]
Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy
Background: No approved treatment for peanut allergy exists for children younger than 4 years of age, and the efficacy and safety of epicutaneous immunotherapy with a peanut patch in toddlers with peanut allergy are unknown. Methods: We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving children 1 to 3 years of age with […]
Primary prevention of cardiovascular disease with a mediterranean diet supplemented with extra-virgin olive oil or nuts.
BACKGROUND: Observational cohort studies and a secondary prevention trial have shown inverse associations between adherence to the Mediterranean diet and cardiovascular risk. METHODS: In a multicenter trial in Spain, we assigned 7447 participants (55 to 80 years of age, 57% women) who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to […]
Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Background Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events. Methods In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular […]
Vitamin E Consumption and the risk of coronary heart disease in women.
BACKGROUND. Interest in the antioxidant vitamin E as a possible protective nutrient against coronary disease has intensified with the recognition that oxidized low-density lipoprotein may be involved in atherogenesis. METHODS. In 1980; 87;245 female nurses 34 to 59 years of age who were free of diagnosed cardiovascular disease and cancer completed dietary questionnaires that assessed […]
Effect of walnuts on serum lipid levels and blood pressure in normal men.
BACKGROUND. In a recent six-year follow-up study; we found that frequent consumption of nuts was associated with a reduced risk of ischemic heart disease. To explore possible explanations for this finding; we studied the effects of nut consumption on serum lipids and blood pressure. METHODS. We randomly placed 18 healthy men on two mixed natural […]
Letter to the editor.
Walnuts and serum lipids.
Vitamin E consumption and the risk of coronary heart disease in men.
BACKGROUND. The oxidative modification of low-density lipoproteins increases their incorporation into the arterial intima; an essential step in atherogenesis. Although dietary antioxidants; such as vitamin C; carotene; and vitamin E; have been hypothesized to prevent coronary heart disease; prospective epidemiologic data are sparse. METHODS. In 1986; 39;910 U.S. male health professionals 40 to 75 years […]