Longitudinal dynamics of the gut microbiome and metabolome in peanut allergy development
Background: Rising rates of peanut allergy motivate investigations of its development to inform prevention and therapy. Microbiota and the metabolites they produce shape food allergy risk. Objective: To gain insight into gut microbiome and metabolome dynamics in the development of peanut allergy. Methods: We performed a longitudinal, integrative study of the gut microbiome and metabolome […]
Food-Induced Anaphylaxis: Data From the European Anaphylaxis Registry
Background: Food is one of the most common elicitors of anaphylaxis, with an increasing incidence over recent years. Objectives: To characterize elicitor-specific phenotypes and identify factors enhancing the risk or severity of food-induced anaphylaxis (FIA). Methods: We analyzed data from the European Anaphylaxis Registry applying an age- and sex-matched analysis of associations (Cramer’s V) for single food triggers […]
Open-label study of the efficacy, safety and durability of peanut sublingual immunotherapy in peanut-allergic children.
Background: Studies are limited on the efficacy of peanut sublingual immunotherapy (SLIT). The durability of desensitization after SLIT has not been well described. Objective: To evaluate the efficacy and safety of 4 mg peanut SLIT and persistence of desensitization after SLIT discontinuation. Methods: Challenge proven peanut-allergic 1-11 year old children were treated with open-label 4 mg peanut SLIT […]
Real-World Safety Analysis of Preschool Tree Nut Oral Immunotherapy.
Background: Our group previously described preschool peanut oral immunotherapy (P-OIT) in a real-world multi-center setting, suggesting this therapy is safe for the vast majority of preschoolers. Objectives: We examined the safety and tolerability of tree nut (TN)-OIT in preschoolers in the real-world. Methods: As part of a Canada-wide quality improvement project, TN-OIT (cashew/pistachio, walnut/pecan, hazelnut, almond, macadamia nut) […]
Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial.
Examining the genetics of peanut allergy (PA) in the context of clinical trial interventions and outcomes provides an opportunity to not only understand gene-environment interactions for PA risk but to also understand the benefit of allergen immunotherapy. A consistent theme in the genetics of food allergy is that in keeping with the dual allergen exposure […]
Narcolepsy-Like Sleepiness: A Symptom of Immediate-Type Reactions in Food-Allergic Children.
Background: It has been reported that sometimes children fall asleep and can barely be woken up during allergic reactions on food ingestion. Nevertheless, to date, there is scarce data on narcolepsy-like sleepiness as a symptom of allergic reactions. Objective: To investigate the frequency of narcolepsy-like sleepiness during oral food challenges and characterize this symptom regarding […]
The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study.
Background: Prospectively collected data on the natural history of food allergy are lacking. Objective: We examined the natural history of egg and peanut allergy in children from age 1 to 6 years and assessed whether a skin prick test (SPT) result or other clinical factors at diagnosis are associated with the persistence or resolution of food allergy […]