A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model

Prostate cancer (PCa) has been linked to fat intake; but the effects of both different dietary fat levels and types remain inconsistent and incompletely characterised. The effects on PCa in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model of an elevated fat (20 % of energy as fat) diet containing 155 g of […]

The effect of X-ray irradiation on Salmonella inactivation and sensory quality of almonds and walnuts as a function of water activity

The overall goal of this study was to develop a set of process design principles for low-energy X-ray irradiation of tree nuts . Almonds and walnuts were inoculated with Salmonella Enteritidis PT30 and Salmonella Tennessee; and conditioned to four different water activities (0.23; 0.45; 0.64; and 0.84 aw). Thereafter; the inoculated/conditioned samples were irradiated to […]

Effects of walnut consumption on cognitive performance in young adults

Walnuts contain a number of potentially neuroprotective compounds like vitamin E; folate; melatonin; several antioxidative polyphenols and significant amounts of n-3 a-linolenic fatty acid. The present study sought to determine the effect of walnuts on verbal and non-verbal reasoning; memory and mood. A total of sixty-four college students were randomly assigned to two treatment sequences […]

Effects of temperature and packaging atmosphere on total antioxidants and colour of walnut (Juglans regia L.) kernels during storage

The effects of cultivar and storage conditions (time; temperature and O2 availability) on total phenolics (TP); total antioxidant capacity (TAC) and colour in walnut kernels of three cultivars (Chandler; Hartley and Ioli) were investigated. Harvested walnuts were dried at 36 °C for 24 h; packaged in polyethylene||polyamide pouches flushed with dry air or N2 or […]

Traditional herbal remedies that influence cell adhesion molecule activity

Many traditional medicines have demonstrated immune activity; however; research has largely neglected their effects on cell adhesion molecules (CAMs). This review reports on extracts from 37 medicinal plant species; similar to or replicating traditional preparations; that up- or down regulate either gene or protein activity of CAMs. The majority of the investigations were in vitro; […]

Antiproliferative and antioxidant activities of Juglans regia fruit extracts

Cancer chemopreventive action of walnut [Juglans regia L. (Juglandaceae)] has been explored. Objective: This study evaluated antiproliferative and antioxidant activities of walnut. Materials and methods: Various fractions of walnut extract have been screened for antiproliferative activity against human cancer cell lines using the MTT assay. All these fractions have also been evaluated for total phenolic […]

Anti-proliferative Effects of Organic Extracts from Root Bark of Juglans Regia L. (RBJR) on MDA-MB-231 Human Breast Cancer Cells: Role of Bcl-2/Bax; Caspases and Tp53

With increasing use of plant-based cancer chemotherapeutic agents; exploring the antiproliferative effects of phytochemicals has gained increasing momentum for anticancer drug design. The present study was undertaken to investigate the effect of root bark of Juglans regia (RBJR) organic extracts on cell proliferation; and to determine the molecular mechanism of RBJR-induced cell death by determining […]

Cardiovascular Effects of Consumption of Black Versus English Walnuts

English walnuts have been shown to decrease cardiovascular disease risk; however; black walnuts do not appear to have not been studied for their cardioprotective effects. The purpose of this study was to determine the effects of English versus black walnut consumption on blood lipids; body weight; fatty-acid composition of red blood cell (RBC) membranes; and […]