Basophil activation test reduces oral food challenges to nuts and sesame.
Background: Nut allergic patients are often IgE sensitized to other nuts/seeds and need multiple oral food challenges (OFCs) before the safe nuts can be introduced in the diet. However, OFCs are time-consuming and risky procedures. Objective: To assess the utility of the basophil activation test (BAT) to predict the allergic status and reduce the need for an […]
Impact of age on adherence and efficacy of peanut oral-immunotherapy using a standardized protocol.
Peanut oral immunotherapy (POIT) has been shown to be an effective therapy in peanut allergic children, as it improves food allergy-related quality of life [1-2] . Randomized controlled trials and observational, real world studies have shown that POIT may be effective and safe in children of all ages, although starting POIT at a younger age may be […]
Reduced peanut sensitization with maternal peanut consumption and early peanut introduction while breastfeeding.
New guidelines for peanut allergy prevention in high-risk infants recommend introducing peanut during infancy but do not address breastfeeding or maternal peanut consumption. We assessed the independent and combined association of these factors with peanut sensitization in the general population CHILD birth cohort (N = 2759 mother-child dyads). Mothers reported peanut consumption during pregnancy, timing […]
IgE-binding to vicilin-like antimicrobial peptides is associated with systemic reactions to macadamia nut.
Background: Macadamia nut can induce fatal allergic reactions and changes in dietary habits will raise their consumption in industrialised countries. Until now diagnosis of macadamia nut allergy by sIgE solely relies on the macadamia nut extract, but single components are lacking. Methods: Macadamia nut proteins recognised by IgE from 2 macadamia nut extract positive sera were identified […]
Usefulness of r Ana o 3 assessment before oral food challenge to pistachio.
Cashew and pistachio both belong to the Anarcardiacae family. Cashew and pistachio allergies may cause severe symptoms such as anaphylaxis with a very low eliciting dose1,2 . The cashew 2S albumin r Ana o 3 is the only singleplex component-resolved diagnosis immunoassay currently available in clinical practice3-5 . Its structural similarity with the pistachio 2S albumin may […]
Food and food products associated with food allergy and food intolerance-An overview.
Immune-mediated food allergy and non-immune mediated food intolerance are categorized as the most common adverse reactions resulting from the ingestion of certain foods. As there is no standard treatment, the possible remedy to avoid exposure to these adverse reactions is adhering to a strict diet that eliminates allergic and intolerant foods. The commonly consumed foods […]
Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study.
Background: Peanut and tree nut allergies are the most important causes of anaphylaxis. Co-reactivity to more than one nut is frequent, and co-sensitization in the absence of clinical data is often obtained. Confirmatory oral food challenges (OFCs) are inconsistently performed. Objective: To investigate the utility of the basophil activation test (BAT) in diagnosing peanut and tree nut […]
The Global Burden of Illness of Peanut Allergy: A Comprehensive Literature Review.
Peanut allergy (PA) currently affects approximately 2% of the general population of Western nations and may be increasing in prevalence. Patients with PA and their families/caregivers bear a considerable burden of self-management to avoid accidental peanut exposure and to administer emergency medication (adrenaline) if needed. Compared with other food allergies, PA is associated with higher […]
Induction of Peanut Allergy Through Inhalation of Peanut in Mice.
Peanut (PN) allergy is a common life-threatening disease; however, our knowledge on the immunological mechanisms remains limited. Here, we describe the first mouse model of inhalation-driven peanut allergy. We administered PN flour intranasally to naïve wild-type mice twice a week for 4 weeks, followed by intraperitoneal challenge with PN extract. Exposure of mice to PN […]
Accurate prediction of peanut allergy in one-third of adults using a validated Ara h 2 cutoff.
Background: The diagnostic value of peanut components is extensively studied in children, but to a lesser extent in adults with suspected peanut allergy. The use of peanut components in daily practice may reduce the need for double-blind placebo-controlled food challenges (DBPCFCs), however validation studies are currently lacking. Objective: To 1) evaluate the diagnostic value of (combined) peanut […]