Ara h 2 is the dominant peanut allergen despite similarities with Ara h 6.
Background: Ara h 2 specific-IgE (sIgE) is to date the best serologic marker to diagnose peanut allergy. Ara h 6 shares ∼60% sequence identity and multiple epitopes with Ara h 2. Objective: To assess the diagnostic utility and relative importance of Ara h 2 and Ara h 6 in peanut allergy. Methods: A cohort (n=100) of peanut allergic […]
Sequence analysis of digestion-resistant peptides may be an efficient strategy for studying the linear epitopes of Jug r 1, the major walnut allergen.
Jug r 1, the major allergen of walnut, triggers severe allergic reactions through epitopes. Hence, research on the efficient strategy for analyzing the linear epitopes of Jug r 1 are necessary. In this work, bioinformatics analysis was used to predict the linear epitopes of Jug r 1. Overlapping peptide synthesis was used to map linear […]
Almond allergens: update and perspective on identification and characterization.
Almond (Prunus dulcis) is widely used as a human food due to its flavor, nutrients, and health benefits, but it is also one of the most likely tree nuts to trigger allergies. Almond allergens, though, have not been studied as extensively as those of peanuts and other selected tree nuts. This work presents an update […]
Influence of Instant Controlled Pressure Drop (DIC) on Allergenic Potential of Tree Nuts.
Pistachio and cashew contain allergenic proteins, which causes them to be removed from the diet of allergic people. Previous studies have demonstrated that food processing (thermal and non-thermal) can produce structural and/or conformational changes in proteins by altering their allergenic capacity. In this study, the influence of instant controlled pressure drop (DIC) on pistachio and […]
Allergen Removal and Transfer Using Wiping and Cleaning Methods in Retail and Food Service Establishments.
Preventing the transfer of allergens from one food to another via food-contact surfaces in retail food environments is an important aspect of retail food safety. Existing recommendations for wiping and cleaning food-contact surfaces is mainly focused on preventing microorganisms such as bacteria and viruses from contaminating foods. The effectiveness of these wiping and cleaning recommendations […]
Updated population minimal eliciting dose distributions for use in risk assessment of 14 priority food allergens.
Food allergy and allergen management are important global public health issues. In 2011, the first iteration of our allergen threshold database (ATDB) was established based on individual NOAELs and LOAELs from oral food challenge in roughly 1750 allergic individuals. Population minimal eliciting dose (EDp) distributions based on this dataset were published for 11 allergenic foods […]
Identification and in silico bioinformatics analysis of PR10 proteins in cashew nut.
Proteins from cashew nut can elicit mild to severe allergic reactions. Three allergenic proteins have already been identified, and it is expected that additional allergens are present in cashew nut. PATHOGENESIS-RELATED PROTEIN 10 (PR10) allergens from pollen have been found to elicit similar allergic reactions as those from nuts and seeds. Therefore, we investigated the […]
A Single Monoclonal Antibody against the Peanut Allergen Ara h 2 Protects against Systemic and Local Peanut Allergy.
Background: Peanut allergy is the most prevalent and dangerous food allergy. Peanuts consist of a large number of different allergens and peanut-allergic patients are frequently sensitized to multiple allergens. Hence, conventional desensitization approaches aim at targeting as many allergens as possible. Methods: The monoclonal anti-Ara h 2 antibody (mAb) was produced by hybridoma cells derived from WT […]
Can my child with IgE‐mediated peanut allergy introduce foods labeled with “may contain traces”?.
Peanut IgE-mediated food allergy is one of the most common food allergies in children with a prevalence that has increased in the past decades in westernized countries. Peanut allergies can trigger severe reactions and usually persist over time. Peanut-allergic children and their families are often confronted to processed foods with precautionary allergen labeling (PAL) such […]
Tree Nuts Anaphylaxis in Preschool Age Children.
Introduction. The incidence of food-induced anaphylaxis (FIA) is increasing in young children. Although the commonest culprits are cow's milk and egg, FIA to tree nuts (TNs) have been increasing. Objective. Characterization of children referred to our allergy department due to TNs-induced anaphylaxis (TNs-FIA) during preschool age. Materials and methods. We have retrospectively included 25 children […]