Identification of New Allergens in Macadamia Nut and Cross-Reactivity with Other Tree Nuts in a Spanish Cohort
The consumption of macadamia nuts has increased due to their cardioprotective and antioxidant properties. However, this rise is consistent with an increase in the cases of macadamia nut allergy, leading to severe reactions. Although two Macadamia integrifolia allergens (Mac i 1 and Mac i 2) have been identified in Australian and Japanese patients, the allergenic […]
Current options in the management of tree nut allergy: A systematic review and narrative synthesis
Tree nut allergy is a lifelong and potentially life-threatening condition. The standard of care is strictly avoiding the culprit nut and treating accidental reactions symptomatically. To evaluate potential therapeutic options for desensitizing patients with IgE-mediated tree nut allergy, we systematically searched three bibliographic databases for studies published until January 2024. We looked for active treatments […]
Design of the Intervention to Reduce Early Peanut Allergy in Children (iREACH): A practice-based clinical trial
Background: Introducing peanut products early can prevent peanut allergy (PA). The “Addendum guidelines for the prevention of PA in the United States” (PPA guidelines) recommend early introduction of peanut products to low and moderate risk infants and evaluation prior to starting peanut products for infants at high risk for PA (those with severe eczema and/or […]
Validation of the NUT CRACKER diagnostic algorithm and prediction for cashew and pistachio co-allergy
Background: Due to the high cross sensitization among tree nuts, the NUT CRACKER study proposed a diagnostic algorithm to minimize the number of required oral food challenges (OFC). Objective: The objective of this study was to validate the algorithm for cashew and pistachio allergy and determine markers for allergic severity. Methods: Patients (n=125) aged 7.9 […]
Long-term Safety Results of Epicutaneous Immunotherapy (EPIT) with Viaskin Peanut in Peanut-Allergic Children Aged 4-11 Years in the Phase 3 PEOPLE Study
Rationale: Previously reported interim results from PEOPLE (PEPITES Open-Label Extension) demonstrated Viaskin Peanut 250 μg (VP250) led to continued treatment response and was well-tolerated out to 3 years. Here we report PEOPLE end-of-study safety results. Methods: In PEPITES, 356 peanut-allergic participants (aged 4-11 years) were randomized to placebo or VP250. In PEOPLE, 298 participants were […]
An Unintentional Randomized Trial of Early Environmental Exposure to Peanut: The Younger Siblings of LEAP Participants
Rationale: The Dual Allergen Exposure Hypothesis proposes that food allergy develops due to cutaneous exposure in the absence of oral consumption. Evaluation of the younger siblings of the Learning Early About Peanut (LEAP) participants provides an opportunity to understand the impact of environmental exposure to peanut during infancy and early childhood on the development of […]
Omalizumab for the Treatment of Multiple Food Allergies
BACKGROUND: Food allergies are common and are associated with substantial morbidity; the only approved treatment is oral immunotherapy for peanut allergy. METHODS: In this trial, we assessed whether omalizumab, a monoclonal anti-IgE antibody, would be effective and safe as monotherapy in patients with multiple food allergies. Persons 1 to 55 years of age who were […]
Prevalence of tree nut allergy in Europe: A systematic review and meta-analysis
In 2014, the European Academy of Allergy and Clinical Immunology (EAACI) published the first systematic review that summarized the prevalence of food allergy (FA) and food sensitization in Europe for studies published 2000-2012. However, only summary estimates for tree nut allergy (TNA) were feasible in that work. In the current update of that systematic review, […]
Systematic review and meta-analyses on the accuracy of diagnostic tests for IgE-mediated food allergy
The European Academy of Allergy and Clinical Immunology (EAACI) is updating the Guidelines on Food Allergy Diagnosis. We aimed to undertake a systematic review of the literature with meta-analyses to assess the accuracy of diagnostic tests for IgE-mediated food allergy. We searched three databases (Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID)) for diagnostic test […]
CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy
Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is known about the B cell memory of persistent IgE responses. Here, we describe, in human pediatric peanut allergy, a population of CD23+IgG1+ memory B cells arising in type 2 immune responses that contain high-affinity peanut-specific clones and generate IgE-producing cells upon activation. The […]