The beneficial effects of tree nuts on the aging brain
Resveratrol; a neuroprotective supplement for Alzheimer's disease
The polyphenolic compound resveratrol (3;4';5-trihydroxystilbene) is a naturally occurring phytochemical which has been found in more than 70 plant species; including herbs and human food products such as grapes; berries; and peanuts. Resveratrol was first isolated in 1940; however; little attention was paid to it until its benefits in coronary heart disease were studied in […]
LMN diet; rich in polyphenols and polyunsaturated fatty acids; improves mouse cognitive decline associated with aging and Alzheimer's disease.
We examined whether LMN diet; reported to induce neurogenesis in adult mice; was able to antagonize the age-related behavioural impairment and neuropathology in wild type (WT) mice and Tg2576 mice; a mouse model of Alzheimer's disease (AD). Thirteen-month-old mice (once the amyloid (AÃ) plaques were formed) were fed with the LMN diet for 5 months; […]
Allergy to hazelnut in adults: A two-step study
BACKGROUND: Although hazelnut consumption is very high in Turkey; the prevalence of hazelnut allergy is still unknown. This study's objective was to investigate the prevalence of hazelnut sensitisation and to verify its clinical importance using double-blind; placebo-controlled challenge (DBPCFC) in an adult population. METHODS: Prick-to-prick skin tests were performed with fresh hazelnut in 904 patients […]
Food combination and Alzheimer disease risk: a protective diet.
OBJECTIVE: To assess the association between food combination and Alzheimer disease (AD) risk. Because foods are not consumed in isolation; dietary pattern (DP) analysis of food combination; taking into account the interactions among food components; may offer methodological advantages. DESIGN: Prospective cohort study. SETTING: Northern Manhattan; New York; New York. PATIENTS OR OTHER PARTICIPANTS: Two […]
New potential AChE inhibitor candidates
We have theoretically studied new potential candidates of acetylcholinesterase (AChE) inhibitors designed from cardanol; a non-isoprenoid phenolic lipid of cashew Anacardium occidentale nut-shell liquid. The electronic structure calculations of fifteen molecule derivatives from cardanol were performed using B3LYP level with 6-31G; 6-31G(d); and 6-311+G(2d;p) basis functions. For this study we used the following groups: methyl; […]
Grape Juice; Berries; and Walnuts Affect Brain Aging and Behavior
Numerous studies have indicated that individuals consuming a diet containing high amounts of fruits and vegetables exhibit fewer age-related diseases such as Alzheimer's disease. Research from our laboratory has suggested that dietary supplementation with fruit or vegetable extracts high in antioxidants (e.g. blueberries; strawberries; walnuts; and Concord grape juice) can decrease the enhanced vulnerability to […]
Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases
Resveratrol is a phytoalexin structurally related to stilbenes; which is synthesized in considerable amounts in the skin of grapes; raspberries; mulberries; pistachios and peanuts; and by at least 72 medicinal and edible plant species in response to stress conditions. It was isolated in 1940 and did not maintain much interest for around five decades until […]
Relation of higher folate intake to lower risk of Alzheimer disease in the elderly
BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels. OBJECTIVE: To relate intake of folate and vitamins B6 and B12 to AD risk. DESIGN AND PATIENTS: We followed up 965 persons 65 years or older without dementia […]