The evidence for dietary prevention and treatment of cardiovascular disease.

During the past few decades numerous studies have reported the atherogenic potential of saturated fatty acids; trans-fatty acids; and cholesterol; and beneficial effects of fiber; phytostanols/phytosterols; n-3 fatty acids; a Mediterranean diet; and other plant-based approaches. The purpose of this article is to provide a comprehensive and systematic review of the evidence associated with key […]

Vitamin E Consumption and the risk of coronary heart disease in women.

BACKGROUND. Interest in the antioxidant vitamin E as a possible protective nutrient against coronary disease has intensified with the recognition that oxidized low-density lipoprotein may be involved in atherogenesis. METHODS. In 1980; 87;245 female nurses 34 to 59 years of age who were free of diagnosed cardiovascular disease and cancer completed dietary questionnaires that assessed […]

Consumption of prunes as a source of dietary fiber in men with mild hypercholesterolemia.

Forty-one free-living adult men with mild hypercholesterolemia (5.2-7.5 mmol/L) voluntarily participated in an 8-wk crossover study designed to determine the effect of prunes as a source of fiber on plasma cholesterol and on fecal output and bile acid concentration. During the prune period, subjects supplemented their usual diets with 12 prunes (100 g; 6 g dietary fiber) daily. Plasma low-density-lipoprotein cholesterol was significantly lower after the prune period (3.9 mmol/L) […]

Pistachio nut consumption and serum lipid levels.

OBJECTIVE: Clinical and epidemiological studies have reported the beneficial effects of tree nuts and peanuts on serum lipid levels. We studied the effects of consuming 15% of the daily caloric intake in the form of pistachio nuts on the lipid profiles of free-living human subjects with primary; moderate hypercholesterolemia (serum cholesterol greater than 210 mg/dL). […]

Serum fatty acids and the risk of stroke

BACKGROUND AND PURPOSE: To examine the relationship between serum fatty acids; which reflect dietary intake; and stroke; we conducted a nested case-control study of 96 men with incident stroke and 96 control subjects matched by age; clinical center; treatment group; and date of randomization who were enrolled in the Multiple Risk Factor Intervention Trial. METHODS: […]

Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high-risk patients (Indo-Mediterranean Diet Heart Study): a randomized single-blind trial.

BACKGROUND: The rapid emergence of coronary artery disease (CAD) in south Asian people is not explained by conventional risk factors. In view of cardioprotective effects of a Mediterranean style diet rich in alpha-linolenic acid; we assessed the benefits of this diet for patients at high risk of CAD. METHODS: We did a randomised; single-blind trial […]