Development of a Buccal tablets for Curcumin using Anacardium occidentale Gum

The objective of the present investigation was to develop uni-directional, bilayered, buccoadhesive tablets of curcumin using a natural buccoadhesive polymer cashew nut tree gum along with ethyl cellulose as an impermeable backing layer. A batch prepared with 20% polymer concentration, 0.1% penetration enhancer, 40 mg backing layer, compressed at 2 tons/cm2 for 10 sec was […]

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

Infections with Shiga toxin (STx)–producing bacteria cause more than a million deaths each year and have no definitive treatment. To exert its cytotoxic effect; STx invades cells through retrograde membrane trafficking; escaping the lysosomal degradative pathway. We found that the widely available metal manganese (Mn2+) blocked endosome-to-Golgi trafficking of STx and caused its degradation in […]

Hexavalent chromium removal from aqueous medium by activated carbon prepared from peanut shell: Adsorption kinetics; equilibrium and thermodynamic studies

Activated carbon was prepared from peanut shell by chemical activation with KOH. Unoxidized activated carbon was prepared in nitrogen atmosphere which was then heated in air at a desired temperature to get oxidized activated carbon. The prepared carbons were characterized for surface area and pore volume and utilized for the removal of Cr(VI) from aqueous […]

Preparation of peanut hull-based activated carbon by microwave-induced phosphoric acid activation and its application in Remazol Brilliant Blue R adsorption

Peanut hull; an agricultural solid waste abundantly available in China; was utilized as a precursor for preparation of activated carbon via microwave induced phosphoric acid chemical activation. To optimize the preparation conditions; the effects of the concentration of phosphoric acid; microwave power and radiation time on the adsorption property (expressed in terms of the iodine […]