Ara h 2-expressing cucumber mosaic virus-like particle (VLP Peanut) induces in vitro tolerogenic cellular responses in peanut-allergic individuals

Background: Peanut allergy (PA) is one of the most prevalent food allergies with a lack of favorable safety/efficacy treatment. A cucumber mosaic virus-like particle expressing peanut allergen component Ara h 2 (VLP Peanut) has been developed as a novel therapeutic approach for PA. Objective: We assessed the tolerogenic properties and reactivity of VLP Peanut. Methods: […]

Peanut Oral Immunotherapy in Children with High-Threshold Peanut Allergy

Background: Approved therapeutics for peanut allergy are not designed for the many patients with allergic reactions to more than one peanut. Methods: We randomly assigned (1:1) participants 4 to 14 years of age reacting to a challenge of between 443 mg and 5043 mg of peanut protein to peanut oral immunotherapy (P-OIT) using home-measured peanut […]

Nut Consumption Is Associated with Cognitive Status in Southern Italian Adults

Background: Nut consumption has been considered a potential protective factor against cognitive decline. The aim of this study was to test whether higher total and specific nut intake was associated with better cognitive status in a sample of older Italian adults. Methods: A cross-sectional analysis on 883 older adults (>50 y) was conducted. A 110-item […]

Consuming Pecans as a Snack Improves Lipids/Lipoproteins and Diet Quality Compared to Usual Diet in Adults at Increased Risk for Cardiometabolic Diseases: A Randomized Controlled Trial

Background: The vascular and cardiometabolic effects of pecans are relatively under-studied. Objectives: The aim was to examine how substitution of usual snack foods with 57 g/day of pecans affects vascular health, risk factors for cardiometabolic diseases and diet quality, compared to continuing usual intake in individuals at risk for cardiometabolic diseases. Methods: A 12-week single-blinded, […]

Virus-Like Particle Vaccine Shows Promise for Peanut Allergy Treatment

The findings provide hope for long-term relief from allergic reactions A recent study published in the Journal of Allergy and Clinical Immunology suggests that a novel virus-like particle vaccine targeting peanut allergy may have the potential to provide a safe and effective alternative to existing treatments. Researchers developed a vaccine using a cucumber mosaic virus-like […]

Study Finds Home-Based Peanut Immunotherapy Effective for Children with High-Threshold Peanut Allergy

The findings point to a convenient, low-cost alternative to total peanut avoidance A recent study published in the prestigious journal NEJM Evidence found that children with high-threshold peanut allergies who consumed gradually increasing doses of peanut butter over 18 months were able to tolerate significantly larger amounts of peanut protein without allergic reactions. Researchers conducted […]

Research Supports Eating Pecans as a Heart-Healthy Snack

Consuming pecans instead of usual snacks may lead to better cholesterol levels and diet quality A recent study published in the American Journal of Clinical Nutrition examined how substituting common snack foods with pecans affects vascular health, risk factors for cardiometabolic diseases, and diet quality. The study was a 12-week randomized controlled trial involving 138 […]

The impact of a walnut-rich breakfast on cognitive performance and brain activity throughout the day in healthy young adults: a crossover intervention trial

A healthy diet is essential for optimal brain health and many bioactives from food are linked to cognitive benefits. To examine whether walnuts led to cognitive improvements throughout the day, 32 healthy young adults, aged 18-30, were tested in a double-blind, crossover pilot study, to compare the effects of a breakfast containing 50 g walnuts […]