Forty-nine prediabetic subjects were included in this trial. Participants consumed a pistachio-supplemented diet (57 g/day, half roasted/half roasted and salted) and a control diet (with the same calorie content) for 4 months each, separated by a 2-weeks washout period. DNA oxidation (the carrier of genetic information) and gene expression related to either oxidation, telomere maintenance or glucose, and insulin metabolism were analyzed.
The study results observed that compared with the control diet, the pistachio diet reduced oxidative damage to DNA. In conclusion, chronic pistachio consumption may help reduce oxidative damage to DNA and increase the gene expression of some telomere-associated genes, which may help revert certain deleterious metabolic consequences of prediabetes.
Canudas, S., Hernández-Alonso, P., Galié, S., Muralidharan, J., Morell-Azanza, L., Zalba, G., … & Bulló, M. (2019). Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial. The American Journal of Clinical Nutrition.
The study results observed that compared with the control diet, the pistachio diet reduced oxidative damage to DNA. In conclusion, chronic pistachio consumption may help reduce oxidative damage to DNA and increase the gene expression of some telomere-associated genes, which may help revert certain deleterious metabolic consequences of prediabetes.
Canudas, S., Hernández-Alonso, P., Galié, S., Muralidharan, J., Morell-Azanza, L., Zalba, G., … & Bulló, M. (2019). Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial. The American Journal of Clinical Nutrition.