Single-tree nut immunotherapy attenuates allergic reactions in mice with hypersensitivity to multiple tree nuts
BACKGROUND: Allergic reactions to tree nuts are often severe and are outgrown in less than 10% of diagnosed patients. OBJECTIVES: To determine whether treatment of underlying tree nut sensitization will prevent allergic reactions to cross-reacting tree nuts and to determine the effects of single-tree nut immunotherapy on true multi-tree nut sensitization. METHODS: Cross-reactivity model: Cashew-sensitized […]
Component-resolved in vitro diagnosis of hazelnut allergy in Europe
BACKGROUND: Food allergy to hazelnut occurs both with and without concomitant pollen allergy. OBJECTIVE: We sought to evaluate a panel of hazelnut allergens for diagnosis of hazelnut allergy in Spain; Switzerland; and Denmark. METHODS: Fifty-two patients with a positive double-blind; placebo-controlled food challenge result with hazelnuts; 5 patients with a history of anaphylaxis; 62 patients […]
Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells
BACKGROUND: Food allergy is a serious and sometimes fatal condition for which there is no cure. We previously reported that Food Allergy Herbal Formula (FAHF)-2) protected peanut-allergic mice against anaphylactic reactions as long as 4 weeks posttherapy. This formula is now in clinical trials in the United States. OBJECTIVE: We sought to determine whether FAHF-2-mediated […]
Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy
BACKGROUND: Despite guidelines recommending avoidance of peanuts during infancy in the United Kingdom (UK); Australia; and; until recently; North America; peanut allergy (PA) continues to increase in these countries. OBJECTIVE: We sought to determine the prevalence of PA among Israeli and UK Jewish children and evaluate the relationship of PA to infant and maternal peanut […]
Advances in allergic skin disease; anaphylaxis; and hypersensitivity reactions to foods; drugs; and insects in 2008
This review highlights some of the research advances in anaphylaxis; and hypersensitivity reactions to foods; drugs; and insects and in allergic skin disease that were reported in the Journal in 2008. Key epidemiologic observations include a rise in anaphylaxis in a population-based study and lower rates of peanut allergy in Israel; where infants consume peanut […]
Production of IL-12 by Peyer patch-dendritic cells is critical for the resistance to food allergy
Background: Dendritic cells (DCs) play a pivotal role in antigen presentation and regulation of immune responses; however; their involvement in food allergy remains to be fully understood. Objective: Our aim was to investigate T(H)1-T(H)2 reciprocal regulation of DCs' function in the gut and systemic immune system and its effect on food allergy in mice with […]
Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study
BACKGROUND: Allergy to peanuts and tree nuts (TNs) is the leading cause of fatal and near-fatal food allergic reactions. Peanut allergy appears to be increasing in prevalence. OBJECTIVES: We sought to determine the prevalence of self-reported peanut and TN allergy among the general population of the United States in 2002 by sex and age and […]
Rising prevalence of allergy to peanut in children: Data from 2 sequential cohorts
BACKGROUND: Allergy to peanut is common. However; it is not known whether the prevalence of sensitization and clinical allergy to peanut is increasing. OBJECTIVE: We sought to determine any change in the prevalence of peanut sensitization and reactivity in early childhood in 2 sequential cohorts in the same geographic area 6 years apart. METHODS: Of […]