In this recent study, published in The Journal of Nutrition, researchers examined the correlation between plasma metabolomics from walnut consumption and cardiovascular health. Through studies on the health benefits of eating walnuts, they identified an association between walnut consumption and lower risk of type 2 diabetes and cardiovascular disease. However, what is not clear, is the relationship between the plasma metabolites connected to walnuts and lower risk of cardiovascular disease.
For the study, 1833 participants with a high risk for cardiovascular disease and metabolomic data available from the PREDIMED study –a large Spanish primary prevention trial– were identified. Of these 1833 participants, 1522 of them also had metabolomic data at year one available. The analysis aimed to associate 385 known metabolites with walnut consumption. Once researchers found a metabolite profile (a new metabolic signature), they evaluated the relationship between the newly identified profile and incident type 2 diabetes and cardiovascular disease.
In conclusion, a total of 19 metabolites were significantly connected with walnut consumption. This metabolite profile, which was linked to walnut consumption, was also found to be associated with a decrease in the risk of incident type 2 diabetes and cardiovascular disease among participants with an existing high cardiovascular risk.
Guasch-Ferré, M., Hernández-Alonso, P., Drouin-Chartier, J. P., Ruiz-Canela, M., Razquin, C., Toledo, E., … & Salas-Salvadó, J. (2020). Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease. The Journal of Nutrition.
For the study, 1833 participants with a high risk for cardiovascular disease and metabolomic data available from the PREDIMED study –a large Spanish primary prevention trial– were identified. Of these 1833 participants, 1522 of them also had metabolomic data at year one available. The analysis aimed to associate 385 known metabolites with walnut consumption. Once researchers found a metabolite profile (a new metabolic signature), they evaluated the relationship between the newly identified profile and incident type 2 diabetes and cardiovascular disease.
In conclusion, a total of 19 metabolites were significantly connected with walnut consumption. This metabolite profile, which was linked to walnut consumption, was also found to be associated with a decrease in the risk of incident type 2 diabetes and cardiovascular disease among participants with an existing high cardiovascular risk.
Guasch-Ferré, M., Hernández-Alonso, P., Drouin-Chartier, J. P., Ruiz-Canela, M., Razquin, C., Toledo, E., … & Salas-Salvadó, J. (2020). Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease. The Journal of Nutrition.