Rapid and accurate detection of peanut pod appearance quality based on lightweight and improved YOLOv5_ SSE model
Introduction: With the escalating demands for agricultural product quality in modern agriculture, peanuts, as a crucial economic crop, have their pod appearance quality directly influencing market value and consumer acceptance. Traditionally, the visual inspection of peanut pod appearance quality relies heavily on manual labor, which is not only labor-intensive and inefficient but also susceptible to […]
Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE
Background: The pivotal phase 3 EPITOPE trial, a 12-month, double-blind, placebo-controlled study of epicutaneous immunotherapy with the VIASKIN® patch containing 250 μg peanut protein (VP250) previously reported significant treatment response vs placebo in peanut-allergic toddlers aged 1-through-3 years. Objective: To assess interim efficacy and safety of VP250 from the first year of the EPITOPE open-label […]
Ara h 2-expressing cucumber mosaic virus-like particle (VLP Peanut) induces in vitro tolerogenic cellular responses in peanut-allergic individuals
Background: Peanut allergy (PA) is one of the most prevalent food allergies with a lack of favorable safety/efficacy treatment. A cucumber mosaic virus-like particle expressing peanut allergen component Ara h 2 (VLP Peanut) has been developed as a novel therapeutic approach for PA. Objective: We assessed the tolerogenic properties and reactivity of VLP Peanut. Methods: […]
Peanut Oral Immunotherapy in Children with High-Threshold Peanut Allergy
Background: Approved therapeutics for peanut allergy are not designed for the many patients with allergic reactions to more than one peanut. Methods: We randomly assigned (1:1) participants 4 to 14 years of age reacting to a challenge of between 443 mg and 5043 mg of peanut protein to peanut oral immunotherapy (P-OIT) using home-measured peanut […]
Halotolerant Pseudomonas-induced alleviation of salt stress and promotion of growth in peanut (Arachis hypogaea)
Salinity stress is a major abiotic factor limiting crop productivity, particularly in sensitive crops like peanuts (Arachis hypogaea). This study evaluated the potential of Pseudomonas geniculata ND09 in alleviating salt stress impacts on peanut growth under controlled and field conditions. In pot experiments, salt stress significantly reduced root and shoot lengths, biomass, and pod yield […]
Safety of oral immunotherapy for cashew nut and peanut allergy in children – a retrospective single-centre study
Aim of the study: Oral immunotherapy (OIT) is increasingly used for the treatment of childhood food allergies, with limited data available on cashew nut OIT. This real-life study investigated the safety and feasibility of cashew nut OIT, comparing it with peanut OIT, with a focus on the up-dosing process. Methods: We analysed cashew nut (n […]
Impact of Heat and Pressure Processing Treatments on the Digestibility of Peanut, Hazelnut, Pistachio and Cashew Allergens
Food processing can alter protein biochemical properties, impacting immunoreactivity and allergenicity. A key feature of food allergens is their resistance to enzymatic digestion, particularly by pepsin and trypsin. This study compares the digestomes of raw and heat- and/or pressure-treated peanuts, hazelnuts, pistachios and cashews using the INFOGEST harmonized digestion protocol and analyzing their IgE-binding capacity […]
Comparing two Peanut Desensitization Protocols in pre-school children: a Real-World Clinical Practice
Background: Peanut allergy is the main food allergy in childhood and poses significant health concerns. Objective: This study aimed to critically evaluate the effectiveness and safety of Oral Immune Therapy (OIT) using crushed peanuts versus peanut puffs. Methods: Children with an allergist diagnosed peanut allergy based on a history of an IgE-mediated reaction and a […]
Safety and adherence of early oral immunotherapy for peanut allergy in a primary care setting: a retrospective cross-sectional study
Background: Peanut allergy is a common food allergy with potentially life-threatening implications. Early oral immunotherapy for peanut allergy (P-EOIT) has been shown to be effective and safe in research and specialty clinic settings. Provision of P-EOIT in primary care would make it available to more patients. We sought to assess the safety of P-EOIT in […]
Air pollution is associated with persistent peanut allergy in the first 10 years
Background: The role of air pollution in eczema and food allergy development remains understudied. Objective: We aimed to assess whether exposure to air pollution is associated with eczema and food allergies in the first 10 years of life. Methods: HealthNuts recruited a population-based sample of 1-year-old infants who were followed up at ages 4, 6, […]