New Meta-Analysis Strengthens Evidence That Nuts May Lower Cardiovascular Risk
The findings refute a study questioning the benefits of nut consumption A systematic review and meta-analysis funded by the International Nut and Dried Fruit Council (INC) has just been published in the prestigious scientific journal Nutrition, Metabolism and Cardiovascular Diseases.[1] The study showed that current evidence provides a good indication that consuming nuts may advantageously […]
Oral Food Challenge in Children with Tree Nut and Peanut Allergy: The Predictive Value of Diagnostic Tests
Food allergy (FA) affects approximately 6-8% of young children, with a peak prevalence at approximately one year of age. Tree nut and peanut allergies are among the main causes of anaphylaxis in the world. The gold standard for the diagnosis of FAs is the oral food challenge (OFC). Other diagnostic tests used in the clinical […]
Peanut allergen characterization and allergenicity throughout development
Introduction: Peanut allergy (PA) in children is a major concern. There is a need for better biological material for both diagnosis and oral immunotherapy (OIT) treatments. The unique state of seeds at early reproductive stages may affect the allergenicity of storage proteins, and impact clinical diagnostic and OIT protocols. The objective of this study was […]
Epicutaneous immunotherapy for the treatment of peanut allergy
Peanut allergy treatment options remain limited, but novel approaches are being studied, including epicutaneous immunotherapy (EPIT). EPIT uses the cutaneous immune system to promote tolerance to food allergens. Viaskin™ Peanut, an approach to EPIT in late-stage clinical development uses an occlusive patch with a condensation chamber that enables natural epidermal water loss to solubilize dry […]
Safety and feasibility of peanut, tree nut, and sesame oral immunotherapy in infants and toddlers in a real-world setting
Background: Oral immunotherapy (OIT) for food allergy has been largely studied in older children within the context of clinical trials, and its availability has historically been limited for younger patients with food allergy. Data has shown that the most impact may actually be seen with the use of OIT in younger infants and toddlers. Objective: […]
Improved Straw Decomposition Products Promote Peanut Growth by Changing Soil Chemical Properties and Microbial Diversity
The ameliorative effects of straw decomposition products on soil acidification have been extensively studied. However, the impact of chemically treated straw decomposition products on crop productivity and the underlying microbial mechanisms remain unclear. This study aimed to investigate the effects of two dosages of Ca(OH)2-treated straw decomposition products of peanuts on red soil acidity, fertility, […]
A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study With Single Blind Sentinel Period to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IGNX001 in Peanut-Allergic Participants
The goal of this randomized, double-blind, placebo-controlled, single ascending dose clinical trial is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of IGNX001 in peanut-allergic adults and older Adolescents. https://clinicaltrials.gov/study/NCT06331728
Successful introduction of peanut in sensitized infants with reported reactions at home
Background and objective: Previous studies have shown efficacy of early introduction of peanut to prevent peanut allergy. It is currently unknown which diagnostic pathway is optimal after parental-reported reactions to peanut at home after early introduction. Methods: The PeanutNL cohort study included high-risk infants that were referred for early introduction of peanut. A subgroup of […]
Tolerance of peanuts and tree nuts in Spanish children with exclusive sensitization to lipid transfer proteins
Background: Allergy to peanuts and tree nuts is a common cause of food allergy in Spain, with lipid transfer proteins (LTP) being the most frequently recognized panallergen. LTP sensitization often leads to multiple food group sensitivities, resulting in overly restrictive diets that hinder patient’s quality of life. This study aimed to assess the tolerance of […]
Prevalence and Determinants of Food Allergy in the Era of Early Allergen Introduction: the EarlyNuts Population-Based Study
Background: Infant feeding guidelines in Australia changed in 2016 to recommend introducing common allergy-causing foods by age 1 year to prevent food allergy. Although most Australian infants now eat peanut and egg by age 6 months, some still develop food allergy despite the early introduction of allergens. Objectives: To describe the prevalence of food allergy […]