Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-allergic Children with Atopic Comorbidities
Background: There is a high prevalence rate of atopic comorbidities, including atopic dermatitis (AD), asthma, and concomitant food allergy (CFA), in children with peanut allergy. Objective: To evaluate whether concomitant atopic comorbidities affect the safety and efficacy of VIASKIN® peanut patch (VP250). Methods: EPITOPE was a phase 3, double-blind, placebo-controlled trial designed to assess treatment […]
Advancements and Impacts of Cold Plasma Technology on Dried Nuts and Related Products
In this review, various dried nuts such as almonds, pistachios, peanuts, walnuts, hazelnuts, mixed nuts, and others were subjected to different cold plasma (CP) techniques under varying processing parameters (e.g., voltage, current, frequency, time). The review examines the impact of these treatments on microbial reduction, sensory attributes, and physicochemical properties of the dried nuts. The […]
Maternal supplementation with α-tocopherol inhibits the development of offspring food allergy, H1R signaling and ultimately anaphylaxis early in life
Food allergy has had a rapid rise in prevalence, and thus it is important to identify approaches to limit the development of food allergy early in life. Because maternal dietary supplementation with α-tocopherol (α-T), an isoform of vitamin E, during pregnancy and nursing increases neonate plasma levels of α-T and can limit neonate development of […]
The prevalence of peanut-triggered food protein-induced enterocolitis syndrome in a prospective cohort of infants introducing peanut in the first year of life
Background: Since the early introduction of peanut to prevent IgE-mediated peanut allergy, other case series have suggested an increased incidence of peanut-triggered Food Protein Induced Enterocolitis Syndrome (FPIES). Data on the prevalence of peanut-induced FPIES in prospective cohorts are lacking. Methods: The PeanutNL cohort is a prospective cohort that included infants at risk of peanut […]
Basophil Activation Test for the Improved Diagnosis of Peanut and Tree Nut Allergy
Purpose of review: As an ex-vivo test of allergic effector cell activation, basophil activation testing (BAT) to allergen enables quantification of the in-vivo IgE-mediated allergic response. BAT thus holds promise in the diagnosis and monitoring of peanut and tree nut allergies. Recent systematic analyses and expert recommendations support a role for BAT in the diagnosis […]
Rapid and accurate detection of peanut pod appearance quality based on lightweight and improved YOLOv5_ SSE model
Introduction: With the escalating demands for agricultural product quality in modern agriculture, peanuts, as a crucial economic crop, have their pod appearance quality directly influencing market value and consumer acceptance. Traditionally, the visual inspection of peanut pod appearance quality relies heavily on manual labor, which is not only labor-intensive and inefficient but also susceptible to […]
Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE
Background: The pivotal phase 3 EPITOPE trial, a 12-month, double-blind, placebo-controlled study of epicutaneous immunotherapy with the VIASKIN® patch containing 250 μg peanut protein (VP250) previously reported significant treatment response vs placebo in peanut-allergic toddlers aged 1-through-3 years. Objective: To assess interim efficacy and safety of VP250 from the first year of the EPITOPE open-label […]
Ara h 2-expressing cucumber mosaic virus-like particle (VLP Peanut) induces in vitro tolerogenic cellular responses in peanut-allergic individuals
Background: Peanut allergy (PA) is one of the most prevalent food allergies with a lack of favorable safety/efficacy treatment. A cucumber mosaic virus-like particle expressing peanut allergen component Ara h 2 (VLP Peanut) has been developed as a novel therapeutic approach for PA. Objective: We assessed the tolerogenic properties and reactivity of VLP Peanut. Methods: […]
Peanut Oral Immunotherapy in Children with High-Threshold Peanut Allergy
Background: Approved therapeutics for peanut allergy are not designed for the many patients with allergic reactions to more than one peanut. Methods: We randomly assigned (1:1) participants 4 to 14 years of age reacting to a challenge of between 443 mg and 5043 mg of peanut protein to peanut oral immunotherapy (P-OIT) using home-measured peanut […]
Halotolerant Pseudomonas-induced alleviation of salt stress and promotion of growth in peanut (Arachis hypogaea)
Salinity stress is a major abiotic factor limiting crop productivity, particularly in sensitive crops like peanuts (Arachis hypogaea). This study evaluated the potential of Pseudomonas geniculata ND09 in alleviating salt stress impacts on peanut growth under controlled and field conditions. In pot experiments, salt stress significantly reduced root and shoot lengths, biomass, and pod yield […]