Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention

Background: A randomized trial demonstrated consumption of peanut from infancy to age 5 years prevented the development of peanut allergy. An extension of that trial demonstrated the effect persisted after 1 year of peanut avoidance. This follow-up trial examined the durability of peanut tolerance at age 144 months after years of ad libitum peanut consumption. […]

Prediction of pediatric peanut oral food challenge outcomes using machine learning

Background: Clinical testing, including food-specific skin and serum IgE level tests, provides limited accuracy to predict food allergy. Confirmatory oral food challenges (OFCs) are often required, but the associated risks, cost, and logistic difficulties comprise a barrier to proper diagnosis. Objective: We sought to utilize advanced machine learning methodologies to integrate clinical variables associated with […]

Long-term Safety Results of Epicutaneous Immunotherapy (EPIT) with Viaskin Peanut in Peanut-Allergic Children Aged 4-11 Years in the Phase 3 PEOPLE Study

Rationale: Previously reported interim results from PEOPLE (PEPITES Open-Label Extension) demonstrated Viaskin Peanut 250 μg (VP250) led to continued treatment response and was well-tolerated out to 3 years. Here we report PEOPLE end-of-study safety results. Methods: In PEPITES, 356 peanut-allergic participants (aged 4-11 years) were randomized to placebo or VP250. In PEOPLE, 298 participants were […]

An Unintentional Randomized Trial of Early Environmental Exposure to Peanut: The Younger Siblings of LEAP Participants

Rationale: The Dual Allergen Exposure Hypothesis proposes that food allergy develops due to cutaneous exposure in the absence of oral consumption. Evaluation of the younger siblings of the Learning Early About Peanut (LEAP) participants provides an opportunity to understand the impact of environmental exposure to peanut during infancy and early childhood on the development of […]

Fe2O3/carbon derived from peanut shell hybrid as an advanced anode for high performance lithium ion batteries

Carbon materials derived from biomass behave sustainability, easy availability, low cost and environmentally benign. And Fe2O3 are considered as promising anodes for high-performance Li-ion batteries (LIBs) because of their rich electrochemical properties, higher theoretical capacity (1007 mAh g−1), non-toxicity, high corrosion resistance and safety. However, the high irreversible capacity loss and poor cycling stability of […]

Yield prediction in a peanut breeding program using remote sensing data and machine learning algorithms

Peanut is a critical food crop worldwide, and the development of high-throughput phenotyping techniques is essential for enhancing the crop’s genetic gain rate. Given the obvious challenges of directly estimating peanut yields through remote sensing, an approach that utilizes above-ground phenotypes to estimate underground yield is necessary. To that end, this study leveraged unmanned aerial […]

Comparative metabolomics analysis reveals secondary cell wall thickening as a barrier to resist Aspergillus flavus infection in groundnut

Aflatoxin contamination caused by Aspergillus flavus significantly threatens food safety and human health. Resistance to aflatoxin is a highly complex and quantitative trait, but the underlying molecular and biochemical mechanisms are poorly understood. The present study aims to identify the resistance-related metabolites in groundnut that influence the defense mechanism against aflatoxin. Here, metabolite profiling of resistant (55–437) […]

Omalizumab for the Treatment of Multiple Food Allergies

BACKGROUND: Food allergies are common and are associated with substantial morbidity; the only approved treatment is oral immunotherapy for peanut allergy. METHODS: In this trial, we assessed whether omalizumab, a monoclonal anti-IgE antibody, would be effective and safe as monotherapy in patients with multiple food allergies. Persons 1 to 55 years of age who were […]