Food allergy immunotherapy: OIT and EPIT.
IgE mediated food allergy remains a significant and growing problem across the globe. Of the various treatment modalities, oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) have been the best studied. Across various studies of OIT for egg, milk and peanut allergy, strong levels of desensitization have been shown. With egg and peanut OIT, a limited […]
Development and Acceptability of a Shared Decision-Making Tool for Commercial Peanut Allergy Therapies.
Background: Shared decision making (SDM) is the process through which patients and their medical provider mutually explore therapy goals, risks/benefits, and treatment options regarding medical care. Decision-aids are tools to help with the values clarification process and assess decisional needs and potential decisional conflicts. Objective: To develop and assess acceptability of a decision-aid for commercial peanut allergy […]
Effect of Sleep Deprivation and Exercise on Reaction Threshold in Adults With Peanut Allergy: A Randomized Controlled Study
Background: Peanut allergy causes severe and fatal reactions. Current food allergen labeling does not address these risks adequately against the burden of restricting food choice for allergic patients because of limited data on thresholds of reactivity and the influence of everyday factors. Objective: We estimated peanut threshold doses for a United Kingdom population with peanut allergy and examined […]
Aflatoxin contaminated degree detection by hyperspectral data using band index.
Aflatoxin is a highly toxic and carcinogenic substance with fluorescence characteristic. To explore the feasibility of detection the degree of aflatoxin contamination using hyperspectral imaging technology, we proposed a machine learning detection method based on support vector machine (SVM) combining band index and narrow band. First, five concentrations of aflatoxin solutions (10ug/L, 20ug/L, 50ug/L, 100ug/L […]
Development of an Escherichia coli-based Electrochemical Biosensor for Mycotoxin Toxicity Detection.
Mycotoxin contamination in food and feed is a global concern because mycotoxin contamination can cause both acute and chronic health effects in humans and animals. In the present work, an Escherichia coli-based biosensor is described for the toxicity assessment of aflatoxin B1 (AFB1) and zearalenone (ZEN). In this electrochemical biosensor, E. coli is used as the […]
Adverse events associated with peanut oral immunotherapy in children–a systematic review and meta-analysis.
While peanut oral immunotherapy (POIT) represents a promising treatment for peanut allergies in children, safety concerns remain a common barrier to widespread adoption. We aimed to systematically assess available evidence to determine the risk and frequency of adverse events occurring during POIT, and examine study-level characteristics associated with their occurrence and severity. A systematic search […]
Critical review on proteotypic peptide marker tracing for six allergenic ingredients in incurred foods by mass spectrometry.
Peptide marker identification is one of the most important steps in the development of a mass spectrometry (MS) based method for allergen detection, since the robustness and sensitivity of the overall analytical method will strictly depend on the reliability of the proteotypic peptides tracing for each allergen. The European legislation in place issues the mandatory […]
Thermal processing of peanut impacts detection by current analytical techniques.
Recalls of spice containing products due to undeclared peanut have highlighted the importance of analytical methods in these foods. We examined the performance of peanut detection methods in cumin and garlic, focusing on quantitative ELISA. Although suitable for qualitative detection, accurate quantitation proved difficult. Roasting of peanut contaminants influenced ELISA results, with raw peanut over-detected […]
Peanut allergy diagnosis: moving from basic to more elegant testing.
Peanut allergy (PNA) is an IgE-mediated immune disorder which merits particular attention due to its impact on the health and quality of life of millions of patients worldwide. PNA tends to develop in early life and resolves in only 20% of peanut-allergic children. It accounts for the majority of severe food-related allergic reactions. An accurate […]
Food Allergy Prevention: More Than Peanut.
Given an apparent increase in food allergies worldwide, the focus on prevention strategies has intensified. Following the Learning Early About Peanut study, there is now a widespread acceptance that peanut should be introduced promptly into the diet of high-risk infants. However, most food allergies are caused by triggers other than peanut and additional prevention strategies […]