Real-World Safety Analysis of Preschool Tree Nut Oral Immunotherapy.
Background: Our group previously described preschool peanut oral immunotherapy (P-OIT) in a real-world multi-center setting, suggesting this therapy is safe for the vast majority of preschoolers. Objectives: We examined the safety and tolerability of tree nut (TN)-OIT in preschoolers in the real-world. Methods: As part of a Canada-wide quality improvement project, TN-OIT (cashew/pistachio, walnut/pecan, hazelnut, almond, macadamia nut) […]
Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial.
Examining the genetics of peanut allergy (PA) in the context of clinical trial interventions and outcomes provides an opportunity to not only understand gene-environment interactions for PA risk but to also understand the benefit of allergen immunotherapy. A consistent theme in the genetics of food allergy is that in keeping with the dual allergen exposure […]
Allergenicity of peanut allergens and its dependence on the structure.
Food allergies are a global food safety problem. Peanut allergies are common due, in part, to their popular utilization in the food industry. Peanut allergy is typically an immunoglobulin E-mediated reaction, and peanuts contain 17 allergens belonging to different families in peanut. In this review, we first introduce the mechanisms and management of peanut allergy, […]
Factors associated with home epinephrine-treated reactions during peanut and tree-nut oral immunotherapy.
Background: Home reactions requiring epinephrine administration, a marker of their severity, restrict the widespread use of oral immunotherapy (OIT), but their risk factors are largely not known. Objective: To identify risk factors for such reactions during OIT to most allergenic foods. Methods: All patients who began OIT for peanut, tree nuts, sesame, or egg allergy […]
Narcolepsy-Like Sleepiness: A Symptom of Immediate-Type Reactions in Food-Allergic Children.
Background: It has been reported that sometimes children fall asleep and can barely be woken up during allergic reactions on food ingestion. Nevertheless, to date, there is scarce data on narcolepsy-like sleepiness as a symptom of allergic reactions. Objective: To investigate the frequency of narcolepsy-like sleepiness during oral food challenges and characterize this symptom regarding […]
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens.
ImmunoglobulinA (IgA) is the predominant antibody isotype in the gut, where it regulates commensal flora and neutralizes toxins and pathogens. The function of food-specific IgA in the gut is unknown but is presumed to protect from food allergy. Specifically, it has been hypothesized that food-specific IgA binds ingested allergens and promotes tolerance by immune exclusion; […]
Expression, purification, characterization, and patient IgE reactivity of new macadamia nut iso-allergen.
Structural and functional information about food allergens is essential for understanding the allergenicity of food proteins. All allergens belong to a small number of protein families. Various allergens from different families have been successfully produced recombinantly in E. coli for their characterization and applications in allergy diagnosis and treatment. However, recombinant hexameric 11S seed storage […]
Food allergen introduction patterns in the first year of life: A US nationwide survey.
Background: Prevention guidelines have changed over the past decade and now recommend the earlier introduction of peanut and egg without delaying the introduction of other food allergens. This paper explored caregiver practices regarding the introduction of food allergens during infancy. Methods: A survey was administered (2021) to a US population-based sample of 3062 caregivers (children […]
Oral immunotherapy using boiled peanuts for treating peanut allergy: An open‐label, single‐arm trial.
Background: Peanut allergy affects 1%–3% of children in Western countries. Boiling peanuts has been demonstrated to result in a hypoallergenic product that may provide a safer way of inducing desensitization in peanut-allergic patients by first inducing tolerance to boiled peanut. We aimed to assess the efficacy and safety of oral immunotherapy (OIT) using sequential doses […]
Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses.
Background: The LEAP study has shown the effectiveness of early peanut introduction in prevention of peanut allergy (PA). In the EAT study, a statistically significant reduction in PA was present only in per-protocol (PP) analyses, which can be subject to bias. Objective: To combine individual-level data from the LEAP and EAT trials and provide robust […]