The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study.
Background: prospectively collected data on the natural history of food allergy are lacking. Objective: we examined the natural history of egg and peanut allergy in children from age 1 to 6 years and assessed whether a skin prick test (SPT) result or other clinical factors at diagnosis are associated with the persistence or resolution of […]
Characteristics of patients diagnosed as non-allergic following food allergy oral immunotherapy referral.
Background: Ascribing food allergy diagnosis to patients who are not allergic is well described, but its implications on oral immunotherapy (OIT) have not been studied. The aim was to study non-allergic patients referred for OIT. Methods: All patients who began OIT at Shamir Medical Center between November 2015 and August 2020 were included. Medical records were reviewed, […]
Proteomic Analysis of Oil-Roasted Cashews Using a Customized Allergen-Focused Protein Database.
Cashews are one of the most prevalent causes of tree nut allergies. However, the cashew proteome is far from complete, which limits the quality of peptide identification in mass spectrometric analyses. In this study, bioinformatics tools were utilized to construct a customized cashew protein database and improve sequence quality for proteins of interest, based on […]
Recent advances in the diagnosis and management of tree nut and seed allergy.
Purpose of review: Tree nut (TN) and seed allergies are frequent, and their prevalence appears to be on the rise. Allergic reactions associated with these foods are more frequently severe, and these allergies tend to persist into adulthood, consequently affecting quality of life. In this review, we summarize recent advances in diagnostic modalities and management strategies […]
Tree Nut-Induced Anaphylaxis in Canadian Emergency Departments: Rate, Clinical Characteristics and Management.
Background: Data are sparce regarding tree nut-induced anaphylaxis (TNA). Objective: We aimed to characterize rate, clinical characteristics, and management of TNA in children (0-17 years old) across Canada, and assess factors associated with severe reactions and epinephrine use. Methods: Between April 2011 and May 2020, data were collected on children presenting to five emergency departments (EDs) in Canada. […]
Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networks
Background: The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes. Methods: Using a systems biology approach, we […]
The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study.
Background: Prospectively collected data on the natural history of food allergy are lacking. Objective: We examined the natural history of egg and peanut allergy in children from age 1 to 6 years and assessed whether a skin prick test (SPT) result or other clinical factors at diagnosis are associated with the persistence or resolution of food allergy […]
Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study.
Background: For young children with peanut allergy, dietary avoidance is the current standard of care. We aimed to assess whether peanut oral immunotherapy can induce desensitisation (an increased allergic reaction threshold while on therapy) or remission (a state of non-responsiveness after discontinuation of immunotherapy) in this population. Methods: We did a randomised, double-blind, placebo-controlled study in five […]
Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study.
Background: Peanuts (PN) and tree nuts (TN) are among the most frequent elicitors of food allergy and can lead to life-threatening reactions. The current advice for allergic patients is to strictly avoid the offending food independently of their individual threshold level, whereas sensitized patients without allergic symptoms should frequently consume the food to avoid (re-)development of […]
Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy: a randomised placebo-controlled study.
Background: For young children with peanut allergy, dietary avoidance is the current standard of care. We aimed to assess whether peanut oral immunotherapy can induce desensitisation (an increased allergic reaction threshold while on therapy) or remission (a state of non-responsiveness after discontinuation of immunotherapy) in this population. Methods: We did a randomised, double-blind, placebo-controlled study in five […]