Prognosis of food-induced anaphylaxis in children: A single-center real-life study
Background: Food allergies are known to resolve over time, but there is little information on the natural history of food-induced anaphylaxis (FIA). Objective: This study aimed to evaluate the natural history of FIA in children and determine the factors that affect prognosis. Methods: Children with FIA who were followed up for at least 3 years, between 2010 and 2020, were […]
Real-life experience with hazelnut oral immunotherapy.
Background: Hazelnut oral immunotherapy (H-OIT), a promising alternative to hazelnut-free diet for patients with hazelnut allergy, has not been extensively studied. Objective: The primary objective was to investigate the effectiveness of H-OIT for hazelnut allergic children. Methods: Retrospective medical record review of children treated by H-OIT in the University Hospital of Lyon (France) was reported. Clinical and laboratory […]
Primary prevention of food allergy in 2021: Update and proposals of French-speaking pediatric allergists.
During the past years, there has been an alarming increase in cases of food allergy and anaphylaxis in ever-younger children. Often, these children have multiple food allergies and food sensitizations, involving allergens with high anaphylactic potential, such as peanuts and nuts, which have a major influence on their quality of life and future. After reviewing […]
Cashew Oral Immunotherapy for Desensitizing Cashew-Pistachio Allergy (Nut CRACKER Study)
Background: Oral immunotherapy (OIT) is a treatment option for patients with milk, egg and peanut allergy, but data on the efficacy and safety of cashew OIT is limited. Methods: A cohort of 50 cashew-allergic patients aged ≥4 years, who were consecutively enrolled into cashew OIT (target dose 4000 mg protein) between 4/2016-12/2019. Fifteen cashew-allergic patients who […]
Multiplex component-based allergen macroarray test is useful to predict clinical reactivity to tree nuts in children.
Tree nut (TN) allergy is one of the most common IgE-mediated food allergies (FAs) during late childhood and cause severe hypersensitivity reactions.1, 2, 3, 4 TNs share common components/epitopes leading to multiple sensitizations and allergies in up to 96.7 and 60.7% of the patients, respectively. It is common practice to exclude all nuts from the […]
Reduced peanut sensitization with maternal peanut consumption and early peanut introduction while breastfeeding.
New guidelines for peanut allergy prevention in high-risk infants recommend introducing peanut during infancy but do not address breastfeeding or maternal peanut consumption. We assessed the independent and combined association of these factors with peanut sensitization in the general population CHILD birth cohort (N = 2759 mother-child dyads). Mothers reported peanut consumption during pregnancy, timing […]
Combining allergen components improves the accuracy of peanut allergy diagnosis.
Background: IgE to peanut often occurs in the absence of peanut allergy. Detection of allergen component sIgE has improved diagnosis and birthed molecular allergen component arrays, in which sensitisation to multiple allergen components can be measured simultaneously. Objective: To improve the diagnostic utility of serology for peanut allergy, by mapping interactions of sIgE to multiple […]
Irradiation technology: An Effective and Promising Strategy for Eliminating Food Allergens.
Food allergies are one of the major health concerns worldwide and have been increasing at an alarming rate in recent times. The elimination of food allergenicity has been an important issue in current research on food. Irradiation is a typical nonthermal treatment technology that can effectively reduce the allergenicity of food, showing great application prospects […]
Identification of vicilin, legumin and antimicrobial peptide 2a as macadamia nut allergens.
Macadamia nut is an increasingly popular food item of a healthy diet. However, macadamia nut is also a potent allergenic food. To date, there is little information about the allergenic proteins involved. In this study, using sera from macadamia nut allergic individuals, four IgE-binding proteins were detected. Their identities were determined by tandem mass spectrometry […]
Epigenetic programming underpins B‐cell dysfunction in peanut and multi‐food allergy.
Objective: Rates of IgE-mediated food allergy (FA) have increased over the last few decades, and mounting evidence implicates disruption of epigenetic profiles in various immune cell types in FA development. Recent data implicate B-cell dysfunction in FA; however, few studies have examined epigenetic changes within these cells. Methods: We assessed epigenetic and transcriptomic profiles in […]