Sex-specific Leukocyte Responses to Peanut Allergen: Uncovering Potential Links to the Molecular Circadian Clock
Food allergies, particularly peanut allergies, are on the rise, affecting ∼10% of the U.S. population and 17% of adults. We explored sex-based differences in inflammatory responses to peanut allergens using a mouse model. Female mice exhibited severe allergic symptoms and a greater drop in body temperature than males when challenged with peanut extract and cholera […]
Infant diet recommendations reduce IgE-mediated egg, peanut and cow’s milk allergies
Background: Meta-analyses of randomized controlled trials have found that introducing eggs and peanuts earlier during infancy reduced egg and peanut allergy risk. Hence, infant feeding advice has dramatically changed from previous recommendations of avoidance to current recommendations of inclusion of common food allergens in infant diets. Objective: To compare the prevalence of IgE-mediated food allergies […]
The kinetics of epitope-specific IgE and IgG4 in early peanut allergy development and resolution
Background: The development and resolution of peanut allergy (PA) was evaluated in children enrolled or screened for the LEAP intervention trial. The development of epitope-specific-immunoglobulin(es-Ig)E and es-IgG4 antibodies was evaluated in a subset of these children to determine whether their PA status could be predicted at 4-11 months of age. Methods: Sera from 386children enrolled […]
The kinetics of early peanut allergy development and resolution in the EAT, LEAP, and PAS cohorts
Background: Little is known about the development and resolution of early peanut allergy (PA). We examined the natural history and biomarkers of PA longitudinally in three cohorts. Methods: PA development was examined in the EAT, LEAP and PAS cohorts. Early PA was defined by skin prick test (SPT) >4mm by 12-months or oral food challenge […]
Exploring quality of life and related clinical factors in children with tree nut allergies
Background: In Türkiye, tree nut allergy (TNA) is the most common form of food allergy, characterized by persistence and the potential for life-threatening reactions. This study aimed to evaluate the quality of life (QoL) of Turkish children aged 0-12 years with IgE-mediated TNA and explore influential factors, including parental anxiety. Materials and methods: Primary caregiver-parents […]
The safety and efficacy of oral immunotherapy compared to epicutaneous immunotherapy in peanut allergen desensitisation amongst the paediatric cohort-a narrative review
Peanut allergies result from a type 1 hypersensitivity reaction, with a prevalence of approximately 1% in children under 5 years of age. The allergens that instigate this reaction are the peanut proteins (Ara h 1-Ara h 8) for which IgE antibodies are specifically produced. Allergen immunotherapy (AIT), despite the uncertainty regarding its mode of action, […]
HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals
Background: Peanut is a major cause of food allergy. HLA genes have been consistently associated with peanut allergy in association studies. To date, however, there have been very few genetic studies of peanut allergy in non-Hispanic Black (Black) individuals, a group disproportionately affected by food allergy. Objective: Our aim was to study the relationship between […]
Walnut threshold dose distribution and safe dose in allergic patients (Nut CRACKER Study)
Background: Walnut is a significant global food allergen, but data relating to population reaction thresholds are limited. This hampers the ability of industry and regulators to undertake allergen risk assessment, increases use of allergen labeling, and impairs patient quality of life. Objective: To describe reaction eliciting doses in a large walnut-allergic population METHODS: Retrospective cohort […]
Open access online calculator predicts peanut allergic reactions with high accuracy
Background: The Peanut Allergy Prediction Web Tool is a newly developed online aid, which calculates the probability of an individual’s allergic reaction based on their SPT, Ara h 2-specific IgE (Ara h 2-sIgE) and/or basophil activation test (BAT) results. Objective: To validate the diagnostic performance of the online tool and assess its ability to discriminate […]
Clinical and laboratory characteristics of cashew nut allergy in Korean children: Findings from a tertiary hospital
Objective: Cashew nut (CN) allergy is becoming increasingly prevalent and represents a major cause of tree nut-induced anaphylaxis in Korean children. This study investigated the clinical characteristics and laboratory findings of CN allergy in Korean children. Patients and methods: Sixty-four children with a history of CN ingestion, who underwent serum CN-specific immunoglobulin E (CN-sIgE) measurements […]