Guidelines for Early Food Introduction and Patterns of Food Allergy

Objective: We aimed to determine whether rates of peanut (or any) immunoglobulin E-mediated food allergy (IgE-FA) changed following the publication of early peanut introduction guidelines and/or addendum guidelines. Methods: Using electronic health record data from the multistate, primary care-based American Academy of Pediatrics Comparative Effectiveness Research through Collaborative Electronic Reporting (CER2) network, we defined preguidelines, […]

From Sensitisation to Tolerance: A Retrospective Study of Tree Nut and Peanut Allergy in Pediatric Patients

Background: Tree nut/Peanut (TN/PN) allergies are among the most common pediatric food allergies, often persisting into later life and posing significant clinical risks. The likelihood of tolerance acquisition varies, and predictive factors remain inadequately defined in clinical practice. Objective: To evaluate the clinical and laboratory features associated with anaphylaxis risk and tolerance development in pediatric […]

Pediatric food allergy prevalence and trends by race and ethnicity

Background: In the United States, food allergies (FAs) disproportionately affect children based on their racial or ethnic heritage, though there are some gaps and discrepancies in the literature about the prevalence of FAs among different groups. Objective: The objective was to analyze clinical data to determine how FA prevalence varies based on race and ethnicity […]

Kinetics of early peanut allergy development and resolution in the EAT, LEAP, and PAS cohorts

Background: Little is known about the development and resolution of early peanut allergy (PA). Objective: We examined the natural history and biomarkers of PA longitudinally in 3 cohorts. Methods: PA development was examined in the Enquiring About Tolerance (EAT), Learning Early About Peanut (LEAP), and Peanut Allergy Sensitization (PAS) cohorts. Early PA was defined by […]

Infant Diet Recommendations Reduce IgE-Mediated Egg, Peanut, and Cow’s Milk Allergies

Background: Meta-analyses of randomized controlled trials have found that introducing eggs and peanuts earlier during infancy reduced egg and peanut allergy risk. Hence, infant feeding advice has dramatically changed from previous recommendations of avoidance to current recommendations of inclusion of common food allergens in infant diets. Objective: To compare the prevalence of IgE-mediated food allergies […]

Exploring quality of life and related clinical factors in children with tree nut allergies

Background: In Türkiye, tree nut allergy (TNA) is the most common form of food allergy, characterized by persistence and the potential for life-threatening reactions. This study aimed to evaluate the quality of life (QoL) of Turkish children aged 0-12 years with IgE-mediated TNA and explore influential factors, including parental anxiety. Materials and methods: Primary caregiver-parents […]

Convergent monoclonal IgE antibodies from peanut allergic patients are multispecific to immunodominant epitopes of unrelated major peanut and tree nut allergens

Background: Convergent selection has been identified in the IgE antibody repertoires of peanut-allergic individuals, primarily targeting the 2S albumin Ara h 2 and cross-reacting with two other major allergens, the vicilin Ara h 1 and the legumin Ara h 3. In this study, we aimed to investigate the structural and functional basis of this cross-reactivity […]

A Growing Concern for Cashew and an Unexpected Risk From Almonds: Data From the Anaphylaxis Registry

Background: Food allergies are a major health concern with rising prevalence. Dietary habits are changing, and information about cashew-induced anaphylaxis is limited. Methods: Cases of tree nut-induced anaphylaxis (TIA) registered from 2007 until April 2024 were extracted from the European Anaphylaxis Registry and analyzed. Results: 1389 cases of TIA out of 5945 registered food-induced reactions […]

Germline-encoded recognition of peanut underlies development of convergent antibodies in humans

Humans develop immunoglobulin G (IgG) antibodies to the foods they consume. In the context of food allergy, allergen-specific IgG antibodies can sequentially class-switch to pathogenic IgE. However, the mechanism underlying the antigenicity of food proteins remains uncharacterized. Here, we identified convergent antibodies arising from different antibody gene rearrangements that bind to the immunodominant peanut allergen […]