Prevention and Treatment of Peanut Allergy
Early introduction of peanut protein reduces allergy prevalence by approximately 80%, with efficacy diminishing as introduction is delayed. Appropriate prevention involves ingestion of approximately 2 g of peanut protein weekly for infants at low risk and 4 to 6 g weekly for infants at high risk. Population-level implementation that targets all infants achieves greater reduction […]
Almond Allergy in Children and Adults: A Narrative Review of Current Knowledge, Clinical Challenges, and Research Gaps
Background: Almond is one of the most widely consumed tree nuts worldwide; however, almond allergy remains poorly characterized. Despite frequent sensitization, the prevalence of clinically relevant almond allergy appears low, contributing to diagnostic uncertainty. This review summarizes current evidence on the epidemiology, clinical manifestations, and diagnostic challenges of almond allergy. Methods: A narrative review was […]
Analysis of the Safety and Efficacy Of At-Home Oral Food Challenges For Almond, Macadamia Nut, Pine Nut and Brazil Nut
Rationale: Supervised oral food challenges (OFCs) are the gold standard for determining allergen tolerance. However, OFCs burden clinicians from the perspective of time, delays to initiation of oral immunotherapy, and barriers for food introduction. Data from in-office OFCs demonstrated high pass rates for almond, macadamia nut, pine nut and Brazil nut: 95%, 86%, 95% and […]
Recent advances in electrochemical biosensors for peanut allergen detection: A comprehensive review
Peanut allergy represents one of the most severe and prevalent food allergies worldwide, posing a significant challenge to public health, regulatory compliance, and food industry practices. Given that strict avoidance remains the only effective preventive strategy, the reliable detection of trace peanut allergens in complex food matrices is essential to protect allergic consumers and to […]
Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults
Background: Peanut (PN) allergy is an IgE-mediated hypersensitivity with a deviated adaptive immune response dominated by IgE-producing B cells and type 2 T cells (Th2). The in vivo immune response upon antigen encounter, for example, after oral food challenge (OFC), has not been investigated over prolonged timeframes. Methods: Here, we investigated the kinetics of allergen-specific […]
Almond Allergy in Children and Adults: A Narrative Review of Current Knowledge, Clinical Challenges, and Research Gaps
Background: Almond is one of the most widely consumed tree nuts worldwide; however, almond allergy remains poorly characterized. Despite frequent sensitization, the prevalence of clinically relevant almond allergy appears low, contributing to diagnostic uncertainty. This review summarizes current evidence on the epidemiology, clinical manifestations, and diagnostic challenges of almond allergy. Methods: A narrative review was […]
Early Introduction and Other Characteristics in Children With Suspected Severe Peanut or Tree Nut Allergy: Finnish Cohort
Aim: Peanut and tree nut allergies are leading causes of food-induced anaphylaxis in children. We aimed to examine early introduction and allergic characteristics in children with suspected severe peanut and/or tree nut allergy. Methods: Children aged 3-16 years with suspected severe peanut and/or tree nut allergy were recruited from Tampere University Hospital, Finland. Eligibility was […]
Allergenicity Reduction in Peanut Allergen Ara h 1 Induced by Ultrasound-Assisted Glycation
This research investigated the impact of ultrasound-assisted glycation (UG) on the allergenicity of the peanut allergen Ara h 1. Spectral analysis showed that the free amino acid content in the UG-G group decreased most significantly, with a simultaneous increase in surface hydrophobicity. Additionally, the digestive stability of Ara h 1 was enhanced after UG treatment. […]
Autoclaved Peanuts Exhibit Reduced Immunoglobulin E Binding and Improved Oral Tolerability
Background: Major peanut allergens are stable and resistant to denaturation under standard cooking conditions, contributing to allergenicity and low rates of developing natural tolerance in allergic individuals. We evaluated the effects of heat and pressure autoclaving on peanut proteins, IgE binding, and oral tolerability. Methods: Raw, roasted, and autoclaved peanut protein extracts were evaluated by […]
Guidelines for Early Food Introduction and Patterns of Food Allergy
Objective: We aimed to determine whether rates of peanut (or any) immunoglobulin E-mediated food allergy (IgE-FA) changed following the publication of early peanut introduction guidelines and/or addendum guidelines. Methods: Using electronic health record data from the multistate, primary care-based American Academy of Pediatrics Comparative Effectiveness Research through Collaborative Electronic Reporting (CER2) network, we defined preguidelines, […]