Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens
A major proportion of allergic reactions to hazelnuts (Corylus avellana) are caused by immunologic cross-reactivity of IgE antibodies to pathogenesis-related class 10 (PR-10) proteins. Intriguingly, the four known isoforms of the hazelnut PR-10 allergen Cor a 1, denoted as Cor a 1.0401-Cor a 1.0404, share sequence identities exceeding 97% but possess different immunologic properties. In […]
Component-Resolved Diagnosis of Hazelnut Allergy in Children
Hazelnuts commonly elicit allergic reactions starting from childhood and adolescence, with a rare resolution over time. The definite diagnosis of a hazelnut allergy relies on an oral food challenge. The role of component resolved diagnostics in reducing the need for oral food challenges in the diagnosis of hazelnut allergies is still debated. Therefore, three electronic […]
Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activation in children
Background: IgE mediates allergic reactions to peanut; however, peanut-specific IgE (sIgE) levels do not always equate to clinical peanut allergy. Qualitative differences between sIgE of peanut sensitized but tolerant (PS) and peanut allergic (PA) individuals may be important. Objective: To assess the influence of IgE characteristics on effector cell activation in peanut allergy. Methods: A […]
Oral immunotherapy for peanut allergy: The con argument
Background: In some countries of the world, peanut allergy represents an important source of anaphylactic reactions. Traditionally treated with the avoidance of responsible allergens, this condition can also be targeted by oral peanut immunotherapy. Methods: In this study, we review the beneficial and side effects of currently available forms of peanut oral immunotherapy (POIT). We […]
Effect of roasted peanut allergen Ara h 3 protein on the sensitization of Caco-2 cells
Background: Roasted peanut is widely loved as a kind of food with rich taste. However, peanut allergy is one of the major threats to human health, which affects about 5% of children and 1.4-2% of adults in the world. Results: To evaluate the sensitization mechanism of peanut allergen Ara h 3, Caco-2 cells as the […]
Food Allergy History and Reaction to Propofol Administration in a Large Pediatric Population
Background: Anaphylaxis to propofol is rare, however providers face a clinical quandary as medication warnings still exist regarding propofol administration to egg-, soy-, and peanut-allergic patients. Aims: The primary aim evaluated the rate of allergic reactions during propofol-containing anesthesia in patients listed allergic to egg, soy, or peanut compared to non-allergic patients who received propofol. The secondary […]
Macadamia nut allergy in children: clinical features and cross-reactivity with walnut
Macadamia nuts, the seeds of Macadamia tetraphylla or Macadamia integrifolia of family Proteaceae, are a familiar food item. Previous case reports of macadamia nut allergy demonstrated the possibility of false negative IgE antibody test results and cross-reactivity of macadamia nut with hazelnut. However, the clinical features of childhood macadamia nut allergy and the cross-reactivity of […]
Oral immunotherapy: The answer to peanut allergy?
Peanut and tree-nut allergies have increased dramatically in prevalence, especially in children. Historically, children with food allergies have been treated through strict avoidance of the allergen. Recently, an oral preparation of peanut allergen (Palforzia) was approved for immunotherapy (ie, desensitization) in children 4 to 17 years old. This article reviews oral immunotherapy and its role […]
Peanuts in the air clinical and experimental studies
Background: Allergic reactions to food allergens usually occur after ingestion. However, fear of reactions to airborne peanut is a common concern for people with peanut allergy. There are no scientific reports on severe reactions with airborne peanut allergen. Objective: To investigate the occurrence of allergic reactions in peanut-allergic children undergoing airborne peanut challenge and to determine levels […]
Evaluation of the Introduction of Allergen Containing Foods: Feeding Infants and Toddlers Study (FITS) 2016
Background: Guidelines on early introduction of allergen-containing foods are evolving; however, little national data exist defining current allergen feeding practices. Objective: To investigate consumption rates of foods containing egg and peanut among infants and toddlers prior to guideline changes in 2017. Methods: The Feeding Infants and Toddlers Study (FITS) 2016 was conducted nationally among 3235 caregivers with a […]