Peanut and tree nut consumption during pregnancy and allergic disease in children—should mothers decrease their intake? Longitudinal evidence from the Danish National Birth Cohort
Background: The relation between maternal peanut intake during pregnancy and allergic disease development in children has been controversial. Objective: We used data from the Danish National Birth Cohort to examine associations between maternal peanut and tree nut intake during pregnancy and allergic outcomes in children at 18 months and 7 years of age. Methods: We […]
Antigen-fixed leukocytes tolerize th2 responses in mouse models of allergy
Allergic diseases; including asthma and food allergies; are an increasing health concern. Immunotherapy is an effective therapeutic approach for many allergic diseases but requires long dose escalation periods and has a high risk of adverse reactions; particularly in food allergy. New methods to safely induce Ag-specific tolerance could improve the clinical approach to allergic disease. […]
The eliciting dose of peanut in double-blind; placebo-controlled food challenges decreases with increasing age and specific IgE level in children and young adults.
Background: Several risk factors for severe anaphylactic reactions to food in daily life are known. However; to date; it is not possible to predict the severity of allergic reactions to food in the individual patient with accuracy. Some studies show that a history of severe reactions is associated with a lower eliciting dose in double-blind; […]
Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome.
Background: Peanut allergy is severe and rarely resolves. Objective: To test the efficacy and safety of a new oral immunotherapy (OIT) protocol for peanut allergy. Method Twenty-two peanut-allergic children underwent oral challenge. OIT was administered by gradual updosing with 2-weekly increments (8-38 weeks) to 800 mg of protein (5 peanuts/day) followed by 30-week maintenance. Oral […]
Skin prick testing and peanut-specific IgE can predict peanut challenge outcomes in preschoolchildren with peanut sensitization.
BACKGROUND: The rise in peanut allergy is a source of considerable burden in the community. A growing number of pre-schoolchildren have been identified as peanut sensitized in the course of investigation of other allergic conditions. Although many have never knowingly ingested peanuts and their clinical reactivity is not known; it has been common practice to […]
A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response
Abstract BACKGROUND: Open-label oral immunotherapy (OIT) protocols have been used to treat small numbers of patients with peanut allergy. Peanut OIT has not been evaluated in double-blind; placebo-controlled trials. OBJECTIVE: To investigate the safety and effectiveness of OIT for peanut allergy in a double-blind; placebo-controlled study. METHODS: In this multicenter study; children ages 1 to […]
Single-tree nut immunotherapy attenuates allergic reactions in mice with hypersensitivity to multiple tree nuts
BACKGROUND: Allergic reactions to tree nuts are often severe and are outgrown in less than 10% of diagnosed patients. OBJECTIVES: To determine whether treatment of underlying tree nut sensitization will prevent allergic reactions to cross-reacting tree nuts and to determine the effects of single-tree nut immunotherapy on true multi-tree nut sensitization. METHODS: Cross-reactivity model: Cashew-sensitized […]
Enzymatic Treatment of Peanut Kernels to Reduce Allergen Levels.
Abstract: This study investigated the use of enzymatic treatment to reduce peanut allergens in peanut kernels as affect by processing conditions. Two major peanut allergens; Ara h 1 and Ara h 2; were used as indicators of process effectiveness. Enzymatic treatment effectively reduced Ara h 1 and Ara h 2 in roasted peanut kernels by […]
Influence of Processing on the Allergenic Properties of Pistachio Nut Assessed in Vitro
Pistachio (Pistacia vera) is a tree nut that has been reported to cause IgE-mediated allergic reactions. This study was undertaken to investigate the distinctions between different cultivars of pistachio nut and the influence of different processing on the IgE-binding capacity of whole pistachio protein extracts. The influence of different processes on allergenicity was investigated using […]
Ellagic acid and polyphenolics present in walnut kernels inhibit in vitro human peripheral blood mononuclear cell proliferation and alter cytokine production
Tree nuts; including walnuts; are important elicitors of food allergy. We examined the ability of walnut kernel polyphenolics and purified ellagic acid (EA) to modulate cytokine production and cellular proliferation from stimulated human peripheral blood mononuclear cells (PBMC). IL-13 and TNF-alpha production decreased while no change was observed in IL-4 production. Paradoxically; EA and the […]