Production of IL-12 by Peyer patch-dendritic cells is critical for the resistance to food allergy
Background: Dendritic cells (DCs) play a pivotal role in antigen presentation and regulation of immune responses; however; their involvement in food allergy remains to be fully understood. Objective: Our aim was to investigate T(H)1-T(H)2 reciprocal regulation of DCs' function in the gut and systemic immune system and its effect on food allergy in mice with […]
Tree nut allergy
Tree nuts are clinically associated with severe immunoglobulin E-mediated systemic allergic reactions independent of pollen allergy and with reactions that are usually confined to the oral mucosa in patients with immunoglobulin E directed toward cross-reacting pollen allergens. The latter reactions can progress to severe and life-threatening episodes in some patients. Many patients with severe tree […]
Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study
BACKGROUND: Allergy to peanuts and tree nuts (TNs) is the leading cause of fatal and near-fatal food allergic reactions. Peanut allergy appears to be increasing in prevalence. OBJECTIVES: We sought to determine the prevalence of self-reported peanut and TN allergy among the general population of the United States in 2002 by sex and age and […]
Detection and stability of the major almond allergen in foods.
Almond major protein (AMP or amandin); the primary storage protein in almonds; is the major allergen recognized by almond-allergic patients. A rabbit antibody-based inhibition ELISA assay for detecting and quantifying AMP in commercial foods has been developed; and this assay; in conjunction with Western blotting analyses; has been applied to the investigation of the antigenic […]
Cashew allergy: observations of 42 children without associated peanut allergy
BACKGROUND: Cashew allergy seems to be increasingly frequent. The goal of the present study was to analyse the clinical features and results of investigations of 42 children with cashew allergy. METHODS: The clinical features and results of skin prick tests; specific IgE assays; and food challenges were analysed. RESULTS: The mean age at first allergic […]
Food allergy to peanuts in France – evaluation of 142 observations
BACKGROUND: The increase in frequency of peanut allergy and fatal cases have been reported. OBJECTIVES: The objective of this study is to document the severity of food allergy to peanuts by evaluating the reactive dose of peanuts and to search for the role of peanut oil. METHODS: This study is carried out on the basis […]
Peanut allergy.
Peanut allergies have become a major health concern in the United States. Peanuts are one of the most common causes of food allergies and along with tree nuts they account for most of the cases of fatal and near-fatal anaphylactic reactions to food. Not only is there a rise in the prevalence of peanut allergies […]
Rising prevalence of allergy to peanut in children: Data from 2 sequential cohorts
BACKGROUND: Allergy to peanut is common. However; it is not known whether the prevalence of sensitization and clinical allergy to peanut is increasing. OBJECTIVE: We sought to determine any change in the prevalence of peanut sensitization and reactivity in early childhood in 2 sequential cohorts in the same geographic area 6 years apart. METHODS: Of […]
Purification; crystallization and initial crystallographic characterization of brazil-nut allergen Ber e 2. Acta Crystallogr Sect F Struct Biol Cryst Commun
Peanut and tree-nut allergies have attracted considerable attention because of their frequency and their lifelong persistence. Brazil-nut (Bertholletia excelsa) allergies have been well documented and the 11S legumin-like seed storage protein Ber e 2 (excelsin) is one of the two known brazil-nut allergens. In this study; Ber e 2 was extracted from brazil-nut kernels and […]
Long-term prospective observational study of patients with peanut and nut allergy after participation in a management plan in England.
BACKGROUND: Peanut and nut allergy is common and the most frequent cause of severe or fatal reactions to foods. Current advice is poor–doctors give an epinephrine injector to patients; without training or advice on nut avoidance–so that further reactions are common and deaths occur. We devised and assessed a management programme providing advice on nut […]