Dietary omega-3 fatty acids; cyclooxygenase-2 genetic variation; and aggressive prostate cancer risk
PURPOSE: Dietary intake of long-chain omega-3 (LC n-3) polyunsaturated fatty acids may reduce inflammation and in turn decrease risk of prostate cancer development and progression. This potential effect may be modified by genetic variation in cyclooxygenase-2 (COX-2); a key enzyme in fatty acid metabolism and inflammation. EXPERIMENTAL DESIGN: We used a case-control study of 466 […]
Walnuts slow growth of breast cancer tumors
Effect of dried plums on colon cancer risk factors in rats
Dried plums (that is; prunes) are a fruit that show promise as a food to lower colon cancer risk; based on their high content of dietary fiber and polyphenolics. In this study; we have examined the effect of diets containing dried plums on the number of colonic precancerous lesions (aberrant crypts; ACs); fecal bile acid […]
Adherence to Mediterranean diet and health status: meta-analysis
OBJECTIVE: To systematically review all the prospective cohort studies that have analyzed the relation between adherence to a Mediterranean diet; mortality; and incidence of chronic diseases in a primary prevention setting. DESIGN: Meta-analysis of prospective cohort studies. DATA SOURCES: English and non-English publications in PubMed; Embase; Web of Science; and the Cochrane Central Register of […]
Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary walnut
Walnuts contain components that may slow cancer growth including omega 3 fatty acids; phytosterols; polyphenols; carotenoids; and melatonin. A pilot study was performed to determine whether consumption of walnuts could affect growth of MDA-MB 231 human breast cancers implanted into nude mice. Tumor cells were injected into nude mice that were consuming an AIN-76A diet […]
In Vitro Activity of Almond Skin Polyphenols for Scavenging Free Radicals and Inducing Quinone Reductase
Observational studies and clinical trials suggest nut intake; including almonds; is associated with an enhancement in antioxidant defense and a reduction in the risk of cancer and cardiovascular disease. Almond skins are rich in polyphenols (ASP) that may contribute to these putative benefits. To assess their potential mechanisms of action; we tested the in vitro […]
Anacardic acid (6-nonadecyl salicylic acid); an inhibitor of histone acetyltransferase; suppresses expression of NF-{kappa}B-regulated gene products involved in cell survival; proliferation; invasion and inflammation through inhibition of I{kappa}B{alpha}
Anacardic acid (6-pentadecylsalicylic acid) is derived from traditional medicinal plants such as cashew nuts and has been linked to anticancer; anti-inflammatory; and radiosensitization activities through a mechanism that is not yet fully understood. Because of the role of NF-kappaB activation in these cellular responses; we postulated that anacardic acid might interfere this pathway. We found […]
Dietary risk factors for colon cancer in a low-risk population.
In a 6-year prospective study; the authors examined the relation between diet and incident colon cancer among 32;051 non-Hispanic white cohort members of the Adventist Health Study (California; 1976-1982) who; at baseline; had no documented or reported history of cancer. The risk of colon cancer was determined from proportional hazards regression with adjustment for age […]