A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model

Prostate cancer (PCa) has been linked to fat intake; but the effects of both different dietary fat levels and types remain inconsistent and incompletely characterised. The effects on PCa in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model of an elevated fat (20 % of energy as fat) diet containing 155 g of […]

Soil aggregation, carbon build up and root zone soil moisture in degraded sloping lands under selected agroforestry based rehabilitation systems in eastern India

Sloping hills ravaged by shifting cultivation often causes soil erosion problems in the downstream cultivated lands. This study was carried out in the highland zone of Eastern India to evaluate selected horti-silvi-pastoral systems in terms of soil carbon build up, soil aggregation and soil moisture retention in a degraded sloping land. The experiment was taken […]

Development of a Buccal tablets for Curcumin using Anacardium occidentale Gum

The objective of the present investigation was to develop uni-directional, bilayered, buccoadhesive tablets of curcumin using a natural buccoadhesive polymer cashew nut tree gum along with ethyl cellulose as an impermeable backing layer. A batch prepared with 20% polymer concentration, 0.1% penetration enhancer, 40 mg backing layer, compressed at 2 tons/cm2 for 10 sec was […]

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

Infections with Shiga toxin (STx)–producing bacteria cause more than a million deaths each year and have no definitive treatment. To exert its cytotoxic effect; STx invades cells through retrograde membrane trafficking; escaping the lysosomal degradative pathway. We found that the widely available metal manganese (Mn2+) blocked endosome-to-Golgi trafficking of STx and caused its degradation in […]

Hexavalent chromium removal from aqueous medium by activated carbon prepared from peanut shell: Adsorption kinetics; equilibrium and thermodynamic studies

Activated carbon was prepared from peanut shell by chemical activation with KOH. Unoxidized activated carbon was prepared in nitrogen atmosphere which was then heated in air at a desired temperature to get oxidized activated carbon. The prepared carbons were characterized for surface area and pore volume and utilized for the removal of Cr(VI) from aqueous […]