Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

Infections with Shiga toxin (STx)–producing bacteria cause more than a million deaths each year and have no definitive treatment. To exert its cytotoxic effect; STx invades cells through retrograde membrane trafficking; escaping the lysosomal degradative pathway. We found that the widely available metal manganese (Mn2+) blocked endosome-to-Golgi trafficking of STx and caused its degradation in […]

Hexavalent chromium removal from aqueous medium by activated carbon prepared from peanut shell: Adsorption kinetics; equilibrium and thermodynamic studies

Activated carbon was prepared from peanut shell by chemical activation with KOH. Unoxidized activated carbon was prepared in nitrogen atmosphere which was then heated in air at a desired temperature to get oxidized activated carbon. The prepared carbons were characterized for surface area and pore volume and utilized for the removal of Cr(VI) from aqueous […]

Preparation of peanut hull-based activated carbon by microwave-induced phosphoric acid activation and its application in Remazol Brilliant Blue R adsorption

Peanut hull; an agricultural solid waste abundantly available in China; was utilized as a precursor for preparation of activated carbon via microwave induced phosphoric acid chemical activation. To optimize the preparation conditions; the effects of the concentration of phosphoric acid; microwave power and radiation time on the adsorption property (expressed in terms of the iodine […]

Association of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids with Incident Atrial Fibrillation in Older Adults: The Cardiovascular Health Study

BACKGROUND: Experimental studies suggest long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) may reduce risk of atrial fibrillation (AF). Prior studies evaluating fish or n-3 PUFA consumption from dietary questionnaires and incident AF have been conflicting. Circulating levels of n-3 PUFA provide an objective measurement of exposure. METHODS AND RESULTS: Among 3;326 US men and women […]