A Prospective Validation of the NUT CRACKER Diagnostic Algorithm for Walnut and Pecan Allergy with Prediction of Severity.
Background: We previously devised an algorithm utilizing skin prick tests (SPT), basophil activation tests (BAT) and co-allergy status to reduce the need for oral food challenges (OFC) in 63 patients with suspected walnut/pecan allergies. Objective: To validate prospectively the NUT CRACKER diagnostic algorithm in a new cohort of patients (n=120) and to study the utility […]
Identification of Pru du 6 as a potential marker allergen for almond allergy.
Background: Oral food challenges have demonstrated that diagnosis of almond allergy based on extract-sIgE tests display low specificity. Molecular allergy diagnosis is expected to improve accuracy, but its value in diagnosing almond allergy remains unknown. Objective: To identify relevant almond allergens and examine their ability to improve almond allergy diagnosis. Methods: IgE-reactive proteins were purified from almond kernels. […]
Walnut Consumption and Cardiac Phenotypes: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Background and aims: Observational studies and clinical trials have shown cardiovascular benefits of nut consumption, including walnuts. However, the relations of walnut consumption with systolic and diastolic function, risk factors for heart failure, are unknown. We examined the associations of walnut consumption with cardiac structure and function parameters in black and white adults enrolled in the […]
Corylus avellana L. modulates neurobehaviour and brain chemistry following high-fat diet.
Consumption of a high-fat diet has adverse impacts on metabolism, neurobehavioral, and neurochemical homeostasis in both humans and experimental animals. Here, we examined the effects of two different cultivars of Corylus avellana L. in a mouse model of metabolic syndrome. Corylus avellana L. reduced weight gain in mice that were treated with a high-fat diet, […]
Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein.
Background: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) […]
An almond-based low carbohydrate diet improves depression and glycometabolism in patients with Type 2 Diabetes through modulating gut microbiota and GLP-1: A randomized controlled trial.
Background: A low carbohydrate diet (LCD) is more beneficial for the glycometabolism in type 2 diabetes (T2DM) and may be effective in reducing depression. Almond, which is a common nut, has been shown to effectively improve hyperglycemia and depression symptoms. This study aimed to determine the effect of an almond-based LCD (a-LCD) on depression and glycometabolism, […]
Beyond Fish Oil Supplementation: The Effects of Alternative Plant Sources of Omega-3 Polyunsaturated Fatty Acids upon Lipid Indexes and Cardiometabolic Biomarkers—An Overview.
Cardiovascular diseases remain a global challenge, and lipid-associated biomarkers can predict cardiovascular events. Extensive research on cardiovascular benefits of omega-3 polyunsaturated fatty acids (n3-PUFAs) is geared towards fish oil supplementation and fish-rich diets. Nevertheless, vegetarianism and veganism are becoming more popular across all segments of society, due to reasons as varied as personal, ethical and […]
The effect of cranberry consumption on lipid metabolism and inflammation in human apolipoprotein AI transgenic mice fed a high-fat and high-cholesterol diet.
Lipid metabolism and inflammation contribute to cardiovascular disease development. This study investigated whether the consumption of cranberry (CR; Vaccinium macrocarpon) can alter high-density lipoprotein (HDL) metabolism and prevent inflammation in mice expressing human apolipoprotein A-I transgene (hApoAITg), which have similar HDL profiles to those of humans. Male hApoAITg mice were fed a modified American Institute of Nutrition-93M […]
Fruit and vegetable intake and risk of frailty in women 60 years old or older.
Background. Prior research has suggested that the antioxidative and anti-inflammatory potential of fruits and vegetables may ameliorate aging-related frailty. Objective. We sought to prospectively examine the association between fruit and vegetable intake and incident frailty in older women. Design. We followed 78,366 nonfrail women aged ≥60 y from the Nurses’ Health Study from 1990 to […]
Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents a prooxidant status and hyperlipidemia in pregnant rats with diabetes.
Background. Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of walnut oil-derived PUFA on glucose metabolism, pregnancy outcomes, oxidative stress, and lipid metabolism in gestational diabetes mellitus. Methods. The GDM rat model was generated by intraperitoneal […]