Usefulness of r Ana o 3 assessment before oral food challenge to pistachio.
Cashew and pistachio both belong to the Anarcardiacae family. Cashew and pistachio allergies may cause severe symptoms such as anaphylaxis with a very low eliciting dose1,2 . The cashew 2S albumin r Ana o 3 is the only singleplex component-resolved diagnosis immunoassay currently available in clinical practice3-5 . Its structural similarity with the pistachio 2S albumin may […]
Preventing food allergy in infancy and childhood: systematic review of randomised controlled trials.
Background: This systematic review of ways to prevent immediate-onset/IgE-mediated food allergy will inform guidelines by the European Academy of Allergy and Immunology (EAACI). Methods: The GRADE approach was used. Eleven databases were searched from 1946 to October 2019 for randomised controlled trials (and large prospective cohort studies in the case of breastfeeding). The studies included heterogeneous interventions, […]
Identification of cross‐reactive allergens in cashew‐and pistachio‐allergic children during oral immunotherapy.
It has been estimated that around 8% of the children in the U.S. suffer from food allergy and of those, 40% are allergic to multiple foods. Among tree nuts, allergies to pistachios are common in those with cashew nut allergy and multiple homologous allergenic components are shared between the two nuts. Three major allergens from […]
Can my child with IgE‐mediated peanut allergy introduce foods labeled with “may contain traces”?.
Peanut IgE-mediated food allergy is one of the most common food allergies in children with a prevalence that has increased in the past decades in westernized countries. Peanut allergies can trigger severe reactions and usually persist over time. Peanut-allergic children and their families are often confronted to processed foods with precautionary allergen labeling (PAL) such […]
Predictive factors of allergy to pistachio in children allergic to cashew nut.
Background: Cashew nut (CN) allergy prevalence has increased over the last few years. In children allergic to CN, complete avoidance of pistachio is usually recommended, but recent study showed that only one third of children allergic to CN were also allergic to pistachio. The aim of our study was to identify predictive factors of allergy to […]
Children with nut allergies have impaired gene expression of toll‐like receptors pathway.
Background: Trends in food allergies prompted investigation into the underlying mechanisms. Genetic and epigenetic factors are of high interest and, in particular, the interplay between genes relating to immune factors directly and indirectly involved in food allergy pathogenesis. We sought to determine potential links between gene expression and epigenetic factors relating to Toll-like receptor (TLR) pathways […]
Peanut allergy diagnosis: moving from basic to more elegant testing.
Peanut allergy (PNA) is an IgE-mediated immune disorder which merits particular attention due to its impact on the health and quality of life of millions of patients worldwide. PNA tends to develop in early life and resolves in only 20% of peanut-allergic children. It accounts for the majority of severe food-related allergic reactions. An accurate […]
Accuracy of component‐resolved diagnostics in peanut allergy: systematic literature review and meta‐analysis.
Background: Peanut allergy diagnosis relies on clinical reactivity to peanut supported by detection of specific IgE (sIgE) antibodies. Extract-based sIgE tests have low specificity, so component-resolved diagnostics may complement whole extract testing. Methods: We systematically collected peanut allergen component data in seven databases and studied the diagnostic accuracy of peanut storage proteins (Arah1, 2, 3), and cross-reactive […]
Allergen components in diagnosing childhood hazelnut allergy: systematic literature review and meta‐analysis
BACKGROUND: Hazelnut-specific IgE antibodies (sIgE) in serum support the diagnosis of hazelnut allergy, but extract-based tests have low diagnostic specificity, commonly leading to over-diagnosis. Measuring sensitization to individual allergen components may enhance the diagnosis of hazelnut allergy. We systematically examined data on diagnostic accuracy of sIgE to commercially available hazelnut components to compare their individual […]
Insights into tree nut and sesame consumption from a cohort of 80 peanut‐allergic children.
Peanut allergy is increasing in prevalence in the US according to reports [1] and has become a global concern. Sensitization to tree nuts is common with reported rates of up to 86% for multi-nut sensitization with increasing age [2] [3]. In addition, peanut allergy has been associated with an increased risk of sesame sensitization and […]