Quantitative Risk Reduction Through Peanut Immunotherapy: Safety Benefits of an Increased Threshold in Europe.
BACKGROUND: The clinical relevance of increasing an allergic individual's peanut sensitivity threshold by immunotherapy, i.e., eliciting dose (ED) to 300 or 1000 mg peanut protein, has not been previously characterized in a European population. In this study, we quantify the clinical benefits of an increased threshold of reaction following immunotherapy for the peanut-allergic individual. METHODS: […]
Early Introduction of Allergenic Foods for the Prevention of Food Allergy from an Asian Perspective–An APAPARI Consensus Statement.
Emerging evidence for the early introduction of allergenic foods for the prevention of food allergies, such as peanut allergy in Western populations, has led to the recent publication of guidelines in the USA and Europe recommending early peanut introduction for high-risk infants with severe eczema or egg allergy. Peanut allergy is, however, much less prevalent […]
The role of dietary interventions in the prevention of IgE‐mediated food allergy in children.
Over the last 30 years, the prevalence of food allergy has been on the rise and remains a disease that can have a significant impact on the quality of life of children and their families. There are several hypotheses that have been suggested to account for the increasing prevalence, but this review will focus on […]
Prediction of cashew nut allergy in sensitised children.
As an alternative to the costly, time-consuming and possibly stressful double-blind, placebo-controlled challenge (DBPCFC) test, a model to predict the risk of cashew nut allergy was studied incorporating patient characteristics, standard diagnostic parameters (specific IgE (sIgE) and Skin Prick Test (SPT)) as well as component resolved diagnosis (CRD).
Phenotypical characterization of peanut allergic children with differences in cross‐allergy to tree nuts and other legumes.
BACKGROUND: Peanut allergy in children is often associated with allergies to tree nuts and/or legumes. The aim of the present study was to analyze in cluster a cohort of children allergic to peanuts and assessed for cross-reactivity to nuts and legumes and to identify different phenotypes. METHODS: We included retrospectively 317 children with peanut allergy […]
Early introduction of food reduces food allergy–Pro.
Over the past two decades we have been debating the question of whether the age of commencement of complementary feeding affects the risk of developing food allergy. We ate up the notion that delayed introduction of more allergenic foods in early childhood, would help overcome the increasing rates of food allergy, then we promptly spat […]
No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial.
BACKGROUND: Previous studies showed that Health-Related Quality of Life (HRQL) significantly improved after the food challenge, with greater improvements in HRQL after a negative outcome than a positive outcome. It is currently unknown whether this also occurs in patients undergoing DBPCFCs with cashew nut in the context of a clinical trial. METHODS: Quality of life […]
A retrospect study into the utility of allergen components in walnut allergy.
Walnut (Juglans regia) and Pecan (Carya illinoinensis) are members of the Juglandaceae family. Walnut and pecan appear similar and share high protein homology with the result that most walnut allergic individuals are also allergic to pecan nut. Walnut is a common allergy in tree nut allergic individuals in the United States and the United Kingdom […]
Ethnic differences in prevalence of cashew nut, pistachio nut and almond allergy.
Allergy to peanuts and tree nuts is one of the most serious food allergies affecting children in English-speaking westernised countries like the USA, UK and Australia. The prevalence of peanut allergy (PA) in these regions is as high as 1-3% and is possibly increasing whereas it appears to be uncommon in developing communities in Africa […]
Prospective investigation on the transfer of Ara h 2, the most potent peanut allergen, in human breast milk.
BACKGROUND: Peanut allergy is one of the most severe food allergies. Whether breast feeding induces tolerance to peanuts or on the contrary, predisposes at risk-babies to occult allergic sensitization to peanuts is still a matter of discussion. We sought to investigate the transfer of the most potent peanut allergen Ara h 2 into human breast […]