Food Grade Fungal Stress on Germinating Peanut Seeds Induced Phytoalexins and Enhanced Polyphenolic Antioxidants
The effects of food grade fungus Rhizopus oligosporus stress on phytochemicals and phytoalexins of germinating peanut seeds were investigated by comparing the metabolic profiles of ungerminated (UG); germinated (G); and germinated seeds under fungal stress (GS). Three types of peanut seeds with different skin color (red; reddish brown; and black) were compared in the process. […]
Alteration of Hepatic Proinflammatory Cytokines is Involved in the Resveratrol-Mediated Chemoprevention of Chemically-Induced Hepatocarcinogenesis
Abstract: Hepatocellular carcinoma (HCC); one of the most common cancers in the world; is a leading cause of cancer-related mortality. HCC develops most frequently in the background of oxidative stress and chronic hepatic inflammation due to viral infections; alcohol abuse as well as exposure to environmental and dietary carcinogens. As the prognosis of HCC is […]
Resveratrol Inhibits Periodontal Pathogens In Vitro
The gram-negative anaerobic bacteria A. actinomycetemcomitans (Aa) and P. gingivalis (Pg) are key components in the aetiology of periodontal disease; and associated hard-tissue destruction. Resveratrol is a phytoalexin; produced naturally by several plants when under attack by bacterial or fungal pathogens. It is found in many foods including mulberries; peanuts and the skin of labrusca […]
Chemical composition and biological activities of Arachis species.
Abstract: Arachis hypogaea; known as the peanut; is native to South America. Peanut seed contains several active components including flavonoids; phenolic acids; phytosterols; alkaloids and stilbenes. Some therapeutic effects have been reported for peanut seed extracts; such as antioxidative; antibacterial; antifungal and anti-inflammatory activities. This paper aims to give an overview of the chemical composition; […]
Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome.
Background: Peanut allergy is severe and rarely resolves. Objective: To test the efficacy and safety of a new oral immunotherapy (OIT) protocol for peanut allergy. Method Twenty-two peanut-allergic children underwent oral challenge. OIT was administered by gradual updosing with 2-weekly increments (8-38 weeks) to 800 mg of protein (5 peanuts/day) followed by 30-week maintenance. Oral […]
Skin prick testing and peanut-specific IgE can predict peanut challenge outcomes in preschoolchildren with peanut sensitization.
BACKGROUND: The rise in peanut allergy is a source of considerable burden in the community. A growing number of pre-schoolchildren have been identified as peanut sensitized in the course of investigation of other allergic conditions. Although many have never knowingly ingested peanuts and their clinical reactivity is not known; it has been common practice to […]
Natural Inhibitors of Pancreatic Lipase as New Players in Obesity Treatment.
Abstract: Obesity is a multifactorial disease characterized by an excessive weight for height due to an enlarged fat deposition such as adipose tissue; which is attributed to a higher calorie intake than the energy expenditure. The key strategy to combat obesity is to prevent chronic positive impairments in the energy equation. However; it is often […]
Chemoprevention in experimental animals
Arial
Biological Activity of Peanut (Arachis hypogaea) Phytoalexins and Selected Natural and Synthetic Stilbenoids
Abstract: The peanut plant (Arachis hypogaea L.); when infected by a microbial pathogen; is capable of producing stilbene-derived compounds that are considered antifungal phytoalexins. In addition; the potential health benefits of other stilbenoids from peanuts; including resveratrol and pterostilbene; have been acknowledged by several investigators. Despite considerable progress in peanut research; relatively little is known […]
Characteristics and pathways of bioactive 4-desmethylsterols; triterpene alcohols and 4a-monomethylsterols; from developing Tunisian cultivars and wild peanut (Arachis hypogaea L.).
ABSTRACT: Seven 4-desmethylsterols; five triterpene alcohols and three 4a-monomethylsterols were identified by GCÂMS during the development of wild peanut; which is Arbi (AraA); and cultivars peanut; which are Trabelsia (AraT) and Chounfakhi (AraC). Our results showed that the maximum level of 4-desmethylsterols (881.07 mg/100 g of oil) was reached at 12 days after flowering (DAF) […]