A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response

Abstract BACKGROUND: Open-label oral immunotherapy (OIT) protocols have been used to treat small numbers of patients with peanut allergy. Peanut OIT has not been evaluated in double-blind; placebo-controlled trials. OBJECTIVE: To investigate the safety and effectiveness of OIT for peanut allergy in a double-blind; placebo-controlled study. METHODS: In this multicenter study; children ages 1 to […]

Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy; lactation and early post-natal life

Abstract: Scores of animal studies demonstrate that seed oils replete with linoleic acid and very low in linolenic acid fed as the exclusive source of fat through pregnancy and lactation result in visual; cognitive; and behavioural deficits in the offspring. Commodity peanut; sunflower; and safflower oils fed to mother rats; guinea pigs; rhesus monkeys; and […]

Ultrasensitive nanogold probe-based immunochromatographic assay for simultaneous detection of total aflatoxins in peanuts.

Abstract: An ultrasensitive immunochromatographic (IC) assay for simultaneous detection of total aflatoxins (AFB1; AFB2; AFG1; and AFG2) was developed to meet the requirement for rapidly monitoring aflatoxins in agro-products. The assay was based on a competitive format and its sensitivity was improved by using a novel criterion to screen the optimal amount of monoclonal antibody […]

Enzymatic Treatment of Peanut Kernels to Reduce Allergen Levels.

Abstract: This study investigated the use of enzymatic treatment to reduce peanut allergens in peanut kernels as affect by processing conditions. Two major peanut allergens; Ara h 1 and Ara h 2; were used as indicators of process effectiveness. Enzymatic treatment effectively reduced Ara h 1 and Ara h 2 in roasted peanut kernels by […]

Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines.

The tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) and the androgen receptor (AR) play important roles in tumor development and progression in prostate carcinogenesis. Among many functions; PTEN negatively regulates the cytoplasmic phosphatidylinositol-3-kinase/AKT anti-apoptotic pathway; and nuclear PTEN affects the cell cycle by also negatively regulating the MAPK pathway via […]

Effects of peanut processing on body weight and fasting plasma lipids.

Peanuts and peanut butter are commonly consumed as a snack; meal component and ingredient in various commercial products. Their consumption is associated with reduced CVD risk and they pose little threat to positive energy balance. However; questions have arisen as to whether product form (e.g. whole nut v. butter) and processing properties (e.g. roasting and […]

The effect of genotype and roasting on the fatty acid composition of peanuts.

The impact of two factors; genotype (G) and treatment (raw or roasted peanut) (T); on the chemical composition of peanuts was studied using a chemometric method and Tukey's test. The peanut genotypes evaluated were cultivar cavalo vermelho (CCV); cultivar cavalo rosa (CCR) and cultivar tatu (CTA); in both raw and roasted states. The total lipid […]

Commercial Peanut (Arachis hypogaea L.) Cultivars in the United States: Phytosterol Composition

Phytosterols in commercially grown Runner; Virginia; and Spanish peanuts (n = 221) from 2005 and 2006 were quantified by a combination of acid hydrolysis and alkaline saponification steps followed by gas chromatography-flame ionization detection and gas chromatography-mass spectrometry analysis of the trimethylsilyl derivatives. Delta(5)-Avenasterol; which partially degrades during acid hydrolysis; was quantified after alkaline saponification […]

Effects of Peanut Processing on Masticatory Performance during Variable Appetitive States

Background. Current evidence indicates that peanut consumption reduces cardiovascular disease risk; while posing little threat to positive energy balance. However; questions have been raised as to whether inter- and intraindividual variability in mastication in response to peanut form and processing properties may influence these health effects; since mastication has the potential to alter the bioaccessibility […]