Profiling of bioactive compounds in cultivars of Runner and Valencia peanut market-types using liquid chromatography/APCI mass spectrometry

Peanuts are classified into four market-types (Runners; Spanish; Virginia and Valencia) Studies on their phytochemical composition have focused mainly on market-types other than Valencia. The objectives of this study are to evaluate the phytochemical composition of cultivars of Valencia and Runner market-types. Extracts of twenty-five peanut cultivars of Runner and Valencia market-types were analyzed using […]

The eliciting dose of peanut in double-blind; placebo-controlled food challenges decreases with increasing age and specific IgE level in children and young adults.

Background: Several risk factors for severe anaphylactic reactions to food in daily life are known. However; to date; it is not possible to predict the severity of allergic reactions to food in the individual patient with accuracy. Some studies show that a history of severe reactions is associated with a lower eliciting dose in double-blind; […]

Resveratrol induces mitochondria-mediated AIF and to a lesser extent caspase-9-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells

Resveratrol (RV); a natural plant polyphenol widely present in foods such as grapes; wine; and peanuts; has an ability to inhibit various stages of carcinogenesis in vitro and in vivo. In this report; we explored the roles of intrinsic and extrinsic apoptotic pathways during RV-induced apoptosis in human lung adenocarcinoma (ASTC-a-1) cells. After exposure of […]

Alteration of Hepatic Proinflammatory Cytokines is Involved in the Resveratrol-Mediated Chemoprevention of Chemically-Induced Hepatocarcinogenesis

Abstract: Hepatocellular carcinoma (HCC); one of the most common cancers in the world; is a leading cause of cancer-related mortality. HCC develops most frequently in the background of oxidative stress and chronic hepatic inflammation due to viral infections; alcohol abuse as well as exposure to environmental and dietary carcinogens. As the prognosis of HCC is […]

Resveratrol Inhibits Periodontal Pathogens In Vitro

The gram-negative anaerobic bacteria A. actinomycetemcomitans (Aa) and P. gingivalis (Pg) are key components in the aetiology of periodontal disease; and associated hard-tissue destruction. Resveratrol is a phytoalexin; produced naturally by several plants when under attack by bacterial or fungal pathogens. It is found in many foods including mulberries; peanuts and the skin of labrusca […]

Natural Inhibitors of Pancreatic Lipase as New Players in Obesity Treatment.

Abstract: Obesity is a multifactorial disease characterized by an excessive weight for height due to an enlarged fat deposition such as adipose tissue; which is attributed to a higher calorie intake than the energy expenditure. The key strategy to combat obesity is to prevent chronic positive impairments in the energy equation. However; it is often […]

Chemical composition and biological activities of Arachis species.

Abstract: Arachis hypogaea; known as the peanut; is native to South America. Peanut seed contains several active components including flavonoids; phenolic acids; phytosterols; alkaloids and stilbenes. Some therapeutic effects have been reported for peanut seed extracts; such as antioxidative; antibacterial; antifungal and anti-inflammatory activities. This paper aims to give an overview of the chemical composition; […]

Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome.

Background: Peanut allergy is severe and rarely resolves. Objective: To test the efficacy and safety of a new oral immunotherapy (OIT) protocol for peanut allergy. Method Twenty-two peanut-allergic children underwent oral challenge. OIT was administered by gradual updosing with 2-weekly increments (8-38 weeks) to 800 mg of protein (5 peanuts/day) followed by 30-week maintenance. Oral […]