Alteration of Hepatic Proinflammatory Cytokines is Involved in the Resveratrol-Mediated Chemoprevention of Chemically-Induced Hepatocarcinogenesis

Abstract: Hepatocellular carcinoma (HCC); one of the most common cancers in the world; is a leading cause of cancer-related mortality. HCC develops most frequently in the background of oxidative stress and chronic hepatic inflammation due to viral infections; alcohol abuse as well as exposure to environmental and dietary carcinogens. As the prognosis of HCC is […]

Targets of red grapes: oxidative damage of DNA and leukaemia cells

Abstract: Vitis vinifera is a widespread crop all over the world. The biophenols present in grapes have a remarkable influence on wine quality and also confer potential health-protecting properties to this fruit. The aim of the present work was to assess the beneficial properties of skin; seeds and pulp of red table grapes (RTG) (Vitis […]

Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells

BACKGROUND: Ursolic acid and its cis- and trans-3-O-p-hydroxycinnamoyl esters have been identified as constituents of American cranberries (Vaccinium macrocarpon); which inhibit tumor cell proliferation. Since the compounds may contribute to berry anticancer properties; their content in cranberries; selected cranberry products; and three other Vaccinium species (V. oxycoccus; V. vitis-idaea and V. angustifolium) was determined by […]

Biological Activity of Peanut (Arachis hypogaea) Phytoalexins and Selected Natural and Synthetic Stilbenoids

Abstract: The peanut plant (Arachis hypogaea L.); when infected by a microbial pathogen; is capable of producing stilbene-derived compounds that are considered antifungal phytoalexins. In addition; the potential health benefits of other stilbenoids from peanuts; including resveratrol and pterostilbene; have been acknowledged by several investigators. Despite considerable progress in peanut research; relatively little is known […]

Changes of platelet antioxidative enzymes during oxidative stress: The protective effect of polyphenol-rich extract from berries of Aronia melanocarpa and grape seeds

Abstract: Aronia melanocarpa fruits (Rosaceae) and grape seeds (seeds of Vitis vinifera; Vitaceae) are two of the richest plant sources of phenolic substances; and they have been shown to have various biological activities. The aim of the present study was to investigate and compare the action of phenolic extracts (at concentrations 5?100??g/mL) of two different […]

Pinolenic acid inhibits human breast cancer MDA-MB-231 cell metastasis in vitro

Pinolenic acid (PNA); a naturally-occurring polyunsaturated fatty acid (PUFA); is found mainly in pine seeds. Although many studies have demonstrated beneficial effects of pine seed oil; there are no reports of the biological effects of PNA on cancer metastasis. The objective of this study was to investigate the effect of PNA on human breast cancer […]

Nuts and health outcomes: new epidemiologic evidence.

This article reviews recent epidemiologic evidence on nut intake and health outcomes. It focuses on studies in which nut consumption is directly assessed or when nuts are included in a dietary score or pattern. Epidemiologic studies have been remarkably consistent in showing an association between nut consumption and a reduced risk of coronary heart disease […]

Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines.

The tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) and the androgen receptor (AR) play important roles in tumor development and progression in prostate carcinogenesis. Among many functions; PTEN negatively regulates the cytoplasmic phosphatidylinositol-3-kinase/AKT anti-apoptotic pathway; and nuclear PTEN affects the cell cycle by also negatively regulating the MAPK pathway via […]

Scientific evidence of interventions using the Mediterranean diet: A systematic review.

The Mediterranean Diet has been associated with greater longevity and quality of life in epidemiological studies; the majority being observational. The application of evidence-based medicine to the area of public health nutrition involves the necessity of developing clinical trials and systematic reviews to develop sound recommendations. The purpose of this study was to analyze and […]