A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model

Prostate cancer (PCa) has been linked to fat intake; but the effects of both different dietary fat levels and types remain inconsistent and incompletely characterised. The effects on PCa in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model of an elevated fat (20 % of energy as fat) diet containing 155 g of […]

Bioactivity and chemical composition of blackcurrant (Ribes nigrum) cultivars with and without pesticide treatment

Eleven blackcurrant cultivars grown with pesticide (PT) and without pesticide treatment (PF) were evaluated to compare the differences in plant growth and physical condition; total anthocyanin content; ascorbic acid content; total antioxidant capacity; effect on prostaglandin E2 (PGE2) production and anticancer cell proliferation activities. Results showed that the yield and growth of PT blackcurrants were […]

In vitro fermented nuts exhibit chemopreventive effects in HT29 colon cancer cells

It is proven that nuts contain essential macro- and micronutrients; e.g. fatty acids; vitamins and dietary fibre (DF). Fermentation of DF by the gut microflora results in the formation of SCFA which are recognised for their chemopreventive potential; especially by influencing cell growth. However; little is known about cellular response to complex fermentation samples of […]

Cancer chemoprevention by nuts: evidence and promises

Chemoprevention is the use of chemical compounds to interfere with the early precancerous stages of carcinogenesis and thereby reverse tumor formation. Many chemopreventive agents; either natural or synthetic; have been identified. Some of the most promising compounds are found in vegetables and fruits. There are numerous mechanisms of action by which these components can intervene […]

Resveratrol induces mitochondria-mediated AIF and to a lesser extent caspase-9-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells

Resveratrol (RV); a natural plant polyphenol widely present in foods such as grapes; wine; and peanuts; has an ability to inhibit various stages of carcinogenesis in vitro and in vivo. In this report; we explored the roles of intrinsic and extrinsic apoptotic pathways during RV-induced apoptosis in human lung adenocarcinoma (ASTC-a-1) cells. After exposure of […]

Antiproliferative and antioxidant activities of Juglans regia fruit extracts

Cancer chemopreventive action of walnut [Juglans regia L. (Juglandaceae)] has been explored. Objective: This study evaluated antiproliferative and antioxidant activities of walnut. Materials and methods: Various fractions of walnut extract have been screened for antiproliferative activity against human cancer cell lines using the MTT assay. All these fractions have also been evaluated for total phenolic […]

Anti-proliferative Effects of Organic Extracts from Root Bark of Juglans Regia L. (RBJR) on MDA-MB-231 Human Breast Cancer Cells: Role of Bcl-2/Bax; Caspases and Tp53

With increasing use of plant-based cancer chemotherapeutic agents; exploring the antiproliferative effects of phytochemicals has gained increasing momentum for anticancer drug design. The present study was undertaken to investigate the effect of root bark of Juglans regia (RBJR) organic extracts on cell proliferation; and to determine the molecular mechanism of RBJR-induced cell death by determining […]

Cranberry Proanthocyanidins Mediate Growth Arrest of Lung Cancer Cells through Modulation of Gene Expression and Rapid Induction of Apoptosis.

Abstract: Cranberries are rich in bioactive constituents purported to enhance immune function; improve urinary tract health; reduce cardiovascular disease and more recently; inhibit cancer in preclinical models. However; identification of the cranberry constituents with the strongest cancer inhibitory potential and the mechanism associated with cancer inhibition by cranberries remains to be elucidated. This study investigated […]